TY  - JOUR
T1  - DRESS Sendromu: Bir Olgu Sunumu
TT  - DRESS Syndrome: A Case Report
AU  - Doğantekin, Cankat
AU  - Çelik, Havva Hilal Ayvaz
AU  - Erturan, İjlal
AU  - Erkılınç, Gamze
AU  - Korkmaz, Selma
AU  - Yıldırım, Mehmet
PY  - 2020
DA  - December
DO  - 10.51261/yiu.2020.00020
JF  - Yüksek İhtisas Üniversitesi Sağlık Bilimleri Dergisi
JO  - YIU Saglik Bil Derg
PB  - Yüksek İhtisas Üniversitesi
WT  - DergiPark
SN  - 2717-8439
SP  - 118
EP  - 120
VL  - 1
IS  - 3
LA  - tr
AB  - ‘DRESS’  Drug Reaction with Eosinophilia and Systemic Symptoms   sendromu akut başlangıçlı ateş, cilt döküntüsü ve multi-sistemik  tutulumla karakterize yaşamı tehdit edebilen, nadir bir ilaç reaksiyonudur.  Patofizyolojisi tam olarak bilinmemekle birlikte, genetik yatkınlığı  bulunan kişilerde ilaçların aren oksit biyoaktif metabolitlerinin yavaş  detoksifikasyonu ve viral ko-infeksiyonlar suçlanmaktadır. On yedi  yaşında erkek hasta, 5 gündür olan tüm vücudu kaplayan kızarık  döküntüler nedeniyle kliniğimize başvurdu. Epilepsi nedeniyle 4 aydır  karbamazepin kullandığını belirten hastanın, başvuru anında 38,5°C  ateşi, karaciğer fonksiyon testlerinde bozukluk, CRP yüksekliği,  lökopeni, trombositopeni ve eozinofilisi mevcuttu. Hastaneye yatırılan  hastada ani görme bulanıklığı gelişti ve kraniyel manyetik rezonans   MR  sonucu normal olarak raporlandı. Görme bulanıklığının ilaca  bağlı eozinofil infiltrasyonundan kaynaklanabileceği düşünüldü. Bu  olgu, ani görme bulanıklığı gelişen nadir bir ‘DRESS’ sendromu vakası  olması nedeniyle sunuldu.
KW  - ilaç ilişkili hipersensitivite sendromu
KW  - antikonvülzan tedavi
KW  - görme bulanıklığı
N2  - DRESS  Drug Reaction with Eosinophilia and Systemic Symptoms   syndrome is a rare, life-threatening drug reaction characterized by acute  onset of fever, skin rash, and multisystemic involvement. Although the  pathophysiology is not exactly known, slow detoxification of arene  oxide bioactive metabolites of drugs and viral coinfections are blamed  in people with genetic predisposition. A 17-year-old male patient was  admitted to our clinic with a rash covering his entire body for 5 days. The  patient, who stated that he had been using carbamazepine for 4 months  due to epilepsy, had fever reaching 38.5°C at the time of admission,  impaired liver function tests, high CRP, leukopenia, thrombocytopenia  and eosinophilia. The patient, who was hospitalized, developed sudden  vision blurriness and the cranial MRI result was reported as normal. It  was thought that the blurriness in the vision could be caused by druginduced eosinophil infiltration. This case is presented as a rare case of  DRESS syndrome with blurred vision.
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CR  - Tas S, Simonart T. Drug rash with eosinophilia and systemic symptoms  DRESS syndrome . Acta Clin Belg 1999;54:197–200. https://doi.org/10.108 0/17843286.1999.11754231
CR  - Callot V, Roujeau JC, Bagot M, Wechsler J, Chosidow O, Souteyrand P, et al. Drug-induced pseudolymphoma and hypersensitivity syndrome. Two different clinical entities. Arch Dermatol 1996;132:1315–1321. https://doi.org/10.1001/ archderm.1996.03890350057010
CR  - Roujeau JC. Clinical heterogeneity of drug hypersensitivity. Toxicology 2005;209:123–129. https://doi.org/10.1016/j.tox.2004.12.022
CR  - Descamps V, Ranger-Rogez S. DRESS syndrome. Joint Bone Spine 2014;81:15–21. https://doi.org/10.1016/j.jbspin.2013.05.002
CR  - Kardaun SH, Sekula P, Valeyrie-Allanore L, Liss Y, Chu C, Creamer D, et al. Drug reaction with eosinophilia and systemic symptoms  DRESS : an original multisystem adverse drug reaction. Results from the prospective RegiSCAR study. Br J Dermatol 2013;169:1071–1080. https://doi.org/10.1111/bjd.12501
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CR  - Oelze LL, Pillow MT. Phenytoin-induced drug reaction with eosinophilia and systemic symptoms  DRESS  syndrome: a case report from the emergency department. J Emerg Med 2013;44:75–78. https://doi.org/10.1016/j. jemermed.2011.05.052
UR  - https://doi.org/10.51261/yiu.2020.00020
L1  - https://dergipark.org.tr/tr/download/article-file/3782957
ER  -