TY - JOUR T1 - Kounis Syndrome Accompanying Diffuse Alveolar Hemorrhage due to Pinaverium Bromide: A Case Report TT - Pinaverium Bromide Bağlı Diffüz Alveoler Hemorajiye Eşlik Eden Kounis Sendromu: Olgu Sunumu AU - Öztürk, Ahmet AU - Güneş, Osmancan AU - Kuşdoğan, Mikail AU - Günay, Serkan AU - Erenler, Ali Kemal PY - 2024 DA - June Y2 - 2024 DO - 10.52827/hititmedj.1451459 JF - Hitit Medical Journal JO - Hitit Medical Journal PB - Hitit Üniversitesi WT - DergiPark SN - 2687-4717 SP - 241 EP - 245 VL - 6 IS - 2 LA - en AB - Kounis syndrome is defined as a coronary artery distortion due to hypersensitivity to various reasons such as drugs, environmental exposure, nutrients, coronary stents, etc. Diffuse alveolar hemorrhage is a life-threatening condition that clinically presents with hypoxemic respiratory distress, low hematocrit level, hemoptysis, and extensive pulmonary infiltration. Drugs involving pinaverium bromide as an active ingredient is frequently used for relieving gastrointestinal complaints. In this report, we present a case of a young female patient with Kounis syndrome accompanying diffuse alveolar hemorrhage admitted to our emergency department due to allergic reaction following Pinaverium Bromide intake. KW - Anaphylaxis KW - diffuse alveolar hemorrhage KW - Kounis Syndrome KW - Pinaverium Bromide N2 - Kounis sendromu, çeşitli nedenlere bağlı olarak koroner arter bozulması olarak tanımlanır. Bu nedenler arasında ilaçlar, çevresel maruziyetler, besinler, koroner stentler vb. yer alabilir. Diffüz alveoler hemoraji hipoksemik solunum sıkıntısı, düşük hematokrit seviyesi, hemoptizi ve geniş pulmoner infiltrasyon ile klinik olarak kendini gösteren hayatı tehdit eden bir durumdur. Pinaverium bromid etken maddesi içeren ilaçlar sıklıkla gastrointestinal şikayetlerin hafifletilmesi için kullanılır. Bu raporda, Pinaverium bromid alımını takiben alerjik reaksiyon nedeniyle Acil Servisimize başvuran ve Kounis sendromu ile birlikte diffüz alveoler hemorajiye sahip genç bir kadın hastayı sunuyoruz. CR - Kounis NG. Kounis syndrome: an update on epidemiology, pathogenesis, diagnosis and therapeutic management. Clin Chem Lab Med 2016;54(10):1545-1559. CR - Raschi E, Fertonani Affini L, Antonazzo IC, Diemberger I, Poluzzi E, De Ponti F. Drug-induced Kounis syndrome: A matter of pharmacovigilance. Int J Cardiol 2019;274:381. CR - Ece Y, Erenler AK, Doğan T. Kounis Syndrome following metamizole infusion. Sakarya Med J 2016;6:170-174. CR - Newsome BR, Morales JE. Diffuse alveolar hemorrhage. South Med J 2011;104(4):269-274. CR - Ioachimescu OC, Stoller JK. Diffuse alveolar hemorrhage: diagnosing it and finding the cause. Cleve Clin J Med 2008;75(4):258-280. CR - Bor S, Lehert P, Chalbaud A, Tack J. Efficacy of pinaverium bromide in the treatment of irritable bowel syndrome: a systematic review and meta-analysis. Therap Adv Gastroenterol 2021;14:17562848211033740. CR - Tsigkas G, Chouchoulis K, Theodoropoulos K, Kounis NG, Alexopoulos D. Allergic reaction reveals a non-lethal late stent thrombosis. A new subtype of Kounis syndrome?. Int J Cardiol 2011;149(2):281-282. UR - https://doi.org/10.52827/hititmedj.1451459 L1 - https://dergipark.org.tr/tr/download/article-file/3788852 ER -