@article{article_1456074, title={Blood Apelin-36 Level in Patients with Depression}, journal={Rize Tıp Dergisi}, volume={1}, pages={1–8}, year={2024}, author={Puşuroğlu, Meltem and Bahçeci, İlkay and Baltacıoğlu, Mehmet and Bahçeci, Bülent and İbik, Yunus Emre}, keywords={Depression, Apelin, Mood Disorders}, abstract={Abstract Aim: Major Depressive Disorder is an important health problem leading to significant disability. Biochemical parameters that can be used in the diagnosis and follow-up of Major Depressive Disorders severity are important for clinicians. The aim of our study was to investigate blood apelin levels in patients with Major Depressive Disorder as a marker for disease severity and diagnosis. Materials and Methods: The study included 30 patients diagnosed with Major Depressive Disorder and 31 healthy controls. Hamilton Depression Scale was applied to the patient group. Blood apelin-36 levels were measured in both groups. Results: Plasma apelin-36 level was 0.363±0.102 ng/ml (min-max: 0.173-0.611) in the patient group and 1.140±0.738 ng/ml (min-max: 0.323-2.547) in the healthy control group. Blood apelin-36 level of the patient group was statistically significantly lower than that of the healthy control group (p <0.001). Conclusion: Blood apelin levels were found to be low in patients with Major Depressive Disorder. Apelin is an endogenous peptide with important physiological roles and looks promising as a biomarker. It’s utility for the diagnosis and follow-up of mood disorders requires further investigation. In this respect, our research contributes to the literature.}, number={1}, publisher={Recep Tayyip Erdoğan Üniversitesi}