@article{article_1468418, title={Impact of Erythrocyte Transfusion on Thiol/Disulfide Homeostasis in Anemic Patients}, journal={Anatolian Journal of Emergency Medicine}, volume={7}, pages={63–66}, year={2024}, DOI={10.54996/anatolianjem.1468418}, author={Coşkun, Selçuk and İçme, Ferhat and Yüzbaşıoğlu, Yücel and Tanrıverdi, Fatih and Pamukçu Günaydın, Gül and Elgormus, Cagri Serdar and Erel, Özcan and Neşelioğlu, Salim}, keywords={Anemi, disulfide, eritrosit transfüzyonu, sulfhidrid bileşikleri, oksidatif stres}, abstract={Aim: Anemia limits oxygen delivery to tissues, potentially leading to increased oxidative stress. This study examined the impact of erythrocyte transfusion on thiol/disulfide homeostasis, a marker of oxidative stress, in anemic patients. Material and Methods: Sixty anemic patients receiving transfusions in emergency department were included in this study. We measured total thiol, native thiol, and disulfide levels in blood samples collected before and after red blood cell transfusion. To isolate the effects of anemia, a subgroup analysis that excluded patients with acute/subacute hemorrhage or aplastic anemia was also done. Results: The concentrations of total thiol (374.24±94.84 to 344.6±88.5) and native thiol (338.91±90.51 to 304.91±90.95) significantly decreased after erythrocyte suspension treatment compared to baseline (P <0.0001). However, the disulfide level increased (17.75±6.63 to 20.97±7.25; p = 0.009). Our findings suggest a potential increase in overall oxidative stress. Conclusion: By giving transfusions to anemic patients one may think that oxidative stress will be reduced due to increased oxygen carrying capacity but our results show the contrary. Our results support that oxidative stress increases in vivo in patients who receive transfusion right after the procedure and this is probably due to increased oxidative stressin stored erythrocyte suspensions.}, number={2}, publisher={Türkiye Acil Tıp Derneği}, organization={No supporting İnstution}