TY  - JOUR
T1  - Use of Fresh Frozen Plasma in a Dramatic Case of ACE-Inhibitor Associated Angioedema
AU  - Güler, Sertaç
AU  - Üçöz Kocaşaban, Dilber
AU  - Ata, Mehmet Ali
AU  - Coşkun Yaş, Secdegül
AU  - Günaydın, Yahya Kemal
PY  - 2024
DA  - September
Y2  - 2024
DO  - 10.55994/ejcc.1469585
JF  - Eurasian Journal of Critical Care
JO  - Eurasian j Crit Care
PB  - Acil Tıp Uzmanları Derneği
WT  - DergiPark
SN  - 2667-8721
SP  - 83
EP  - 84
VL  - 6
IS  - 2
LA  - en
AB  - Angioedema describes a non-dependent, non-pitting and transient edema caused by the accumulation of vasoactive substances in the circulation. These vasoactive substances increase vascular permeability, causing swelling of the deep dermal, submucosal or subcutaneous tissues of the face, lips, neck, extremities or gastrointestinal tract. Urticaria may or may not accompany this condition. Angioedema is generally mediated through two pathways: histamine-mediated and bradykinin-mediated. Histamine-mediated angioedema generally responds to standard therapeutic measures (such as antihistamines, steroids and epinephrine), whereas bradykinin-mediated angioedema can be more difficult to manage in emergency departments (ED). Here, we present a patient who presented to our ED with bradykinin-mediated ACE-I-associated dramatic angioedema clinic, did not respond to standard treatments, rapidly improved with fresh frozen plasma (FFP) administration and was discharged after 6 days of follow-up in the emergency critical intensive care unit.
KW  - angioedema
KW  - fresh frozen plasma
KW  - emergency medicine
CR  - 1.	Long BJ, Koyfman A, Gottlieb M. Evaluation and Management of Angioedema in the Emergency Department. West J Emerg Med. 2019;20(4):587-600. doi: 10.5811/westjem.2019.5.42650.
CR  - 2.	Sangha L, Ravichander B, Egwom P, Mishagina I. What Is Next? - The Role of Fresh Frozen Plasma in Refractory Angioedema. Am J Respir Crit Care Med. 2023;207:A3061.
CR  - 3.	Karim MY, Masood A. Fresh-frozen plasma as a treatment for life-threatening ACE-inhibitor angioedema. Journal of Allergy and Clinical Immunology. 2002;109(2):370-1.
CR  - 4.	Kostis WJ, Shetty M, Chowdhury YS, Kostis JB. ACE Inhibitor-Induced Angioedema: a Review. Curr Hypertens Rep. 2018;20(7):55. doi: 10.1007/s11906-018-0859-x.
CR  - 5.	Beaudin J, Colancecco M, Dargin J, Hansen C. Administration of fresh frozen plasma in ACE inhibitor-induced angioedema does not reduce ICU or hospital length of stay. Chest. 2022;161(6):A12.
UR  - https://doi.org/10.55994/ejcc.1469585
L1  - https://dergipark.org.tr/tr/download/article-file/3867654
ER  -