TY  - JOUR
T1  - Are potential bisphenol-A substitutes really safe for aquatic life? Impact on primary producers
TT  - Potansiyel bisphenol-A ikameleri sucul yaşam için gerçekten güvenli mi? Birincil üreticiler üzerindeki etkisi
AU  - Benas, Koray
AU  - Çakal Arslan, Özlem
PY  - 2024
DA  - September
Y2  - 2024
DO  - 10.12714/egejfas.41.3.05
JF  - Ege Journal of Fisheries and Aquatic Sciences
JO  - EgeJFAS
PB  - Ege Üniversitesi
WT  - DergiPark
SN  - 2148-3140
SP  - 207
EP  - 212
VL  - 41
IS  - 3
LA  - en
AB  - Bisphenol A threat to environmental health and human health and has been added to the Candidate List as Very High Concern Substances by the European Chemicals Agency. This led to the replacement of bisphenol A (BPA) with bisphenol analogues, which were considered "safer". However, there are very few scientific studies on the impact of BPA analogues on the environment. In this study, three analogues bisphenol B (BPB), bisphenol A diglycidyl ether (BADGE) and bisphenol F diglycidyl ether (BFDGE) were selected to investigate their ecotoxicological effects on the marine phytoplankton species Phaeodactylum tricornutum, which is representative of primary producers. Phaeodactylum tricornutum was exposed to different concentrations (0.5, 0.8, 1.0, 1.5, 2.0 mg/L) of BPB, BADGE and BFDGE analogues for 72 hours and the toxicity values of three BPA analogues were calculated by OECD 201 algal growth inhibition assay (IC50/EC50). In the light of the data obtained, algal growth inhibition (IC50/EC50) values for marine phytoplankton Phaeodactylum tricornutum were determined as 3.91 mg-BPA/L, 7.83 mg-BPB/L, 5.69 mg-BFDGE/L, 11.71 mg-BADGE/L. The results revealed that BPB, BFDGE and BADGE showed lower toxicity to Phaeodactylum tricornutum compared to BPA algal growth inhibition (3.91 mg-BPA/L). Therefore, it is necessary to share the results of the adverse effects of BPA analogues on aquatic organisms and to conduct ecotoxicological risk assessments.
KW  - Bisphenol analogues
KW  - marine phytoplankton
KW  - algal growth inhibition test
KW  - toxicity
KW  - Phaeodactylum tricornutum
N2  - Bisfenol A çevre sağlığı ve insan sağlığı için tehdit oluşturmaktadır ve “Avrupa Kimyasallar Ajansı” tarafından “Çok Yüksek Önem Arz Eden Maddeler” olarak aday listeye eklenmiştir. Bu durum, bisfenol A'nın (BPA) "daha güvenli" olduğu düşünülen bisfenol analogları ile değiştirilmesine yol açmıştır. Bununla birlikte, BPA analoglarının çevre üzerindeki etkisine ilişkin çok az bilimsel çalışma bulunmaktadır. Bu çalışmada, birincil üreticileri temsil eden deniz fitoplankton türü Phaeodactylum tricornutum üzerindeki ekotoksikolojik etkilerini araştırmak için üç analog bisfenol B (BPB), bisfenol A diglisidil eter (BADGE) ve bisfenol F diglisidil eter (BFDGE) seçilmiştir. Phaeodactylum tricornutum BPB, BADGE ve BFDGE analoglarının farklı konsantrasyonlarına (0.5, 0.8, 1.0, 1.5, 2.0 mg/L) 72 saat boyunca maruz bırakılmış ve üç BPA analoğunun toksisite değerleri OECD 201 alg büyüme inhibisyonu deneyi (IC50/EC50) ile hesaplanmıştır. Elde edilen veriler ışığında, deniz fitoplanktonu Phaeodactylum tricornutum için alg büyüme inhibisyonu (IC50/EC50) değerleri 3.91 mg-BPA/L, 7.83 mg-BPB/L, 5.69 mg-BFDGE/L, 11.71 mg-BADGE/L olarak belirlenmiştir. Sonuçlar BPB, BFDGE ve BADGE'nin Phaeodactylum tricornutum için BPA alg büyüme inhibisyonuna (3.91 mg-BPA/L) kıyasla daha düşük toksisite gösterdiğini ortaya koymuştur. Bu nedenle, BPA analoglarının sucul organizmalar üzerindeki olumsuz etkilerinin sonuçlarının paylaşılması ve ekotoksikolojik risk değerlendirmelerinin yapılması gerekmektedir.
CR  - Akhbarizadeh, R., Moore, F., Monteiro, C., Fernandes, J.O., & Cunha, S.C. (2020). Occurrence, trophic transfer, and health risk assessment of bisphenol analogues in seafood from the Persian Gulf. Marine Pollution Bulletin, 154, 111036. https://doi.org/10.1016/j.marpolbul.2020.111036
CR  - Andersson, N., Arena, M., Auteri, D., Barmaz, S., Grignard, E., Kienzler, A., Lepper, P., Lostia, A.M., Munn, S., Parra Morte, J.M., Pellizzato, F., Tarazona, J., Terron, A., & Van der Linden, S. (2018). Guidance for the identification of endocrine disruptors in the context of Regulations (EU) No 528/2012 and (EC) No 1107/2009. European Food Safety Authority (EFSA) Journal, 16(6), 5311. https://doi.org/10.2903/j.efsa.2018.5311
CR  - Anonymous. (1984). OECD guideline for testing of chemicals 201. Organisation of Economic Cooperation and Development.
CR  - Ballesteros-Gómez, A., Brandsma, S.H., De Boer, J., & Leonards, P.E.G. (2014). Analysis of two alternative organophosphorus flame retardants in electronic and plastic consumer products: Resorcinol bis-(diphenylphosphate) (PBDPP) and bisphenol A bis-(diphenylphosphate) (BPA BDPP). Chemosphere, 116, 10 14. https://doi.org/10.1016/j.chemosphere.2013.12.099
CR  - Bello, A., Xue, Y., & Bello, D. (2021). Urinary biomonitoring of occupational exposures to bisphenol A diglycidyl ether (BADGE)-based epoxy resins among construction painters in metal structure coating. Environment International, 156, 106632. https://doi.org/10.1016/j.envint.2021.106632
CR  - Biles, J.E., White, K.D., McNeal, T.P., & Begley, T.H. (1999). Determination of the diglycidyl ether of bisphenol A and its derivatives in canned foods. Journal of Agricultural and Food Chemistry, 47(5), 1965-1969. https://doi.org/10.1021/jf9810867
CR  - Bishop‐Bailey, D., Hla, T., & Warner, T.D. (2000). Bisphenol A diglycidyl ether (BADGE) is a PPARγ agonist in an ECV304 cell line. British Journal of Pharmacology, 131(4), 651-654. https://doi.org/10.1038/sj.bjp.0703628
CR  - Cakal Arslan, Ö., Gülsever, G., Nalbantlar, B., Boyacioglu, M., & Karaaslan, M.A. (2024). Effects of bisphenol A and new analogues on algal growth of Phaeodactylum tricornutum: A new finding with marine diatom Phaeodactylum tricornutum. European Journal of Biomedical and Pharmaceutical Sciences, 11(1), 08-15.
CR  - Chen, M.Y., Ike, M., & Fujita, M. (2002). Acute toxicity, mutagenicity, and estrogenicity of bisphenol‐A and other bisphenols. Environmental Toxicology: An International Journal, 17(1), 80 86. https://doi.org/10.1002/tox.10035
CR  - Coulier, L., Bradley, E.L., Bas, R.C., Verhoeckx, K.C., Driffield, M., Harmer, N., & Castle, L. (2010). Analysis of reaction products of food contaminants and ingredients: Bisphenol A diglycidyl ether (BADGE) in canned foods. Journal of Agricultural and Food Chemistry, 58(8), 4873-4882. https://doi.org/10.1021/jf904160a
CR  - Cunha, S.C., Almeida, C., Mendes, E., & Fernandes, J.O. (2011). Simultaneous determination of bisphenol A and bisphenol B in beverages and powdered infant formula by dispersive liquid–liquid micro-extraction and heart-cutting multidimensional gas chromatography-mass spectrometry. Food Additives and Contaminants, 28(4), 513-526. https://doi.org/10.1080/19440049.2010.542551
CR  - Czarny, K., Krawczyk, B., & Szczukocki, D. (2021). Toxic effects of bisphenol A and its analogues on cyanobacteria Anabaena variabilis and Microcystis aeruginosa. Chemosphere, 263, 128299. https://doi.org/10.1016/j.chemosphere.2020.128299
CR  - Deanin, R.D. (1975). Additives in plastics. Environmental Health Perspectives, 11, 35-39. https://doi.org/10.1289/ehp.751135
CR  - Diler, Ö., Özil, Ö., Nane, İ.D., Nazıroğlu, M., Minaz, M., Aslankoç, R., Özmen, Ö., & Atsatan, K. (2022). The effects of bisphenol A on oxidative stress, antioxidant defence, histopathological alterations and lysozyme activity in narrow-clawed crayfish (Pontastacus leptodactylus). Turkish Journal of Fisheries and Aquatic Sciences, 22(10). https://doi.org/10.4194/TRJFAS19877
CR  - Gao, Y., Xiao, S.K., Wu, Q., & Pan, C.G. (2023). Bisphenol analogues in water and sediment from the Beibu Gulf, South China Sea: Occurrence, partitioning and risk assessment. Science of The Total Environment, 857, 159445. https://doi.org/10.1016/j.scitotenv.2022.159445
CR  - Grumetto, L., Montesano, D., Seccia, S., Albrizio, S., & Barbato, F. (2008). Determination of bisphenol A and bisphenol B residues in canned peeled tomatoes by reversed-phase liquid chromatography. Journal of Agricultural and Food Chemistry, 56(22), 10633-10637. https://doi.org/10.1021/jf802297z
CR  - Guillard, R.R. (1975). Culture of phytoplankton for feeding marine invertebrates. In Walter L. Smith & Matoira H. Chanley (Ed.), Culture of marine invertebrate animals: Proceedings-1st conference on culture of marine invertebrate animals (pp. 29-60). Springer US.
CR  - Guo, R., Du, Y., Zheng, F., Wang, J., Wang, Z., Ji, R., & Chen, J. (2017). Bioaccumulation and elimination of bisphenol A (BPA) in the alga Chlorella pyrenoidosa and the potential for trophic transfer to the rotifer Brachionus calyciflorus. Environmental Pollution, 227, 460-467. https://doi.org/10.1016/j.envpol.2017.05.010
CR  - Kim, S.S., Hwang, K.S., Yang, J.Y., Chae, J.S., Kim, G.R., Kan, H., & Bae, M.A. (2020). Neurochemical and behavioral analysis by acute exposure to bisphenol A in zebrafish larvae model. Chemosphere, 239, 124751. https://doi.org/10.1016/j.chemosphere.2019.124751
CR  - Kovalakova, P., Cizmas, L., McDonald, T.J., Marsalek, B., Feng, M., & Sharma, V.K. (2020). Occurrence and toxicity of antibiotics in the aquatic environment: A review. Chemosphere, 251, 126351. https://doi.org/10.1016/j.chemosphere.2020.126351
CR  - Lane, R.F., Adams, C.D., Randtke, S.J., & Carter, R.E.Jr. (2015). Bisphenol diglycidyl ethers and bisphenol A and their hydrolysis in drinking water. Water Research, 72, 331 339. https://doi.org/10.1016/j.watres.2014.09.043
CR  - Liu, Y., Guan, Y., Gao, Q., Tam, N.F.Y., & Zhu, W. (2010). Cellular responses, biodegradation and bioaccumulation of endocrine disrupting chemicals in marine diatom Navicula incerta. Chemosphere, 80(5), 592-599. https://doi.org/10.1016/j.chemosphere.2010.03.042
CR  - Liu, J., Zhang, L., Lu, G., Jiang, R., Yan, Z., & Li, Y. (2021). Occurrence, toxicity and ecological risk of bisphenol A analogues in aquatic environment – A review. Ecotoxicology and Environmental Safety, 208, 111481. https://doi.org/10.1016/j.ecoenv.2020.111481
CR  - Lucarini, F., Krasniqi, T., Bailat Rosset, G., Roth, N., Hopf, N.B., Broillet, M.C., & Staedler, D. (2020). Exposure to new emerging bisphenols among young children in Switzerland. International Journal of Environmental Research and Public Health, 17(13), 4793. https://doi.org/10.3390/ijerph17134793
CR  - Marqueno, A., Perez-Albaladejo, E., Flores, C., Moyano, E., & Porte, C. (2019). Toxic effects of bisphenol A diglycidyl ether and derivatives in human placental cells. Environmental Pollution, 244, 513-521. https://doi.org/10.1016/j.envpol.2018.10.045
CR  - Mihaich, E.M., Friederich, U., Caspers, N., Hall, A.T., Klecka, G.M., Dimond, S.S., & Hentges, S.G. (2009). Acute and chronic toxicity testing of bisphenol A with aquatic invertebrates and plants. Ecotoxicology and Environmental Safety, 72(5), 1392 1399. https://doi.org/10.1016/j.ecoenv.2009.02.005
CR  - Minaz, M., Er, A., Ak, K., Nane, İ.D., İpek, Z.Z., Yalçın, A., & Kayış, Ş. (2022a). Investigation of long-term bisphenol A exposure on rainbow trout (Oncorhynchus mykiss): Hematological parameters, biochemical indicator, antioxidant activity, and histopathological examination. Chemosphere, 303, 135136. https://doi.org/10.1016/j.chemosphere.2022.135136
CR  - Minaz, M., Er, A., Ak, K., Nane, İ.D., İpek, Z.Z., Kurtoğlu, İ.Z., & Kayış, Ş. (2022b). Short-term exposure to bisphenol A (BPA) as a plastic precursor: Hematological and behavioral effects on Oncorhynchus mykiss and Vimba vimba. Water, Air, & Soil Pollution, 233(4), 122. https://doi.org/10.1007/s11270-022-05585-x
CR  - Minaz, M., & Kurtoğlu, İ. Z. (2024). Long-term exposure of endangered Danube sturgeon (Acipenser gueldenstaedtii) to bisphenol A (BPA): Growth, behavioral, histological, genotoxic, and hematological evaluation. Environmental Science and Pollution Research, 31(21), 30836-30848. https://doi.org/10.1007/s11356-024-33168-2
CR  - Muhamad, M.S., Salim, M.R., Lau, W.J., & Yusop, Z. (2016). A review on bisphenol A occurrences, health effects and treatment process via membrane technology for drinking water. Environmental Science and Pollution Research, 23, 11549-11567. https://doi.org/10.1007/s11356-016-6357-2
CR  - OECD (2011). OECD guidelines for the testing of chemicals: Freshwater alga and cyanobacteria, growth inhibition test. Organisation Economic Cooperation Development, 1-25.
CR  - Olea, N., Pulgar, R., Pérez, P., Olea-Serrano, F., Rivas, A., Novillo-Fertrell, A., & Sonnenschein, C. (1996). Estrogenicity of resin-based composites and sealants used in dentistry. Environmental Health Perspectives, 104(3), 298. https://doi.org/10.1289/ehp.96104298
CR  - Ou, J., Hu, L., Hu, L., Li, X., & Zou, H. (2006). Determination of phenolic compounds in river water with on-line coupling bisphenol A imprinted monolithic precolumn with high performance liquid chromatography. Talanta, 69(4), 1001-1006. https://doi.org/10.1016/j.talanta.2005.12.003
CR  - Özdamar, K. (1999). Statistical data analysis with package programmes. Kaan Publication. (in Turkish)
Paerl, H.W., & Justic, D. (2011). Primary producers: Phytoplankton ecology and trophic dynamics in coastal waters. In Encyclopedia of Inland Waters (pp. 1-25). https://doi.org/10.1016/B978-0-12-374711-2.00603-3
CR  - Pascoe, D., Carroll, K., Karntanut, W., & Watts, M.M. (2002). Toxicity of 17α-ethinylestradiol and bisphenol A to the freshwater cnidarian Hydra vulgaris. Archives of Environmental Contamination and Toxicology, 43, 56-63. https://doi.org/10.1007/s00244-001-0016-3
CR  - Poole, A., van Herwijnen, P., Weideli, H., Thomas, M.C., Ransbotyn, G., & Vance, C. (2004). Review of the toxicology, human exposure and safety assessment for bisphenol A diglycidylether (BADGE). Food Additives & Contaminants, 21, 905-919. https://doi.org/10.1080/02652030400007294
CR  - Simoneau, C., Theobald, A., Hannaert, P., Roncari, P., Roncari, A., Rudolph, T., & Anklam, E. (1999). Monitoring of bisphenol-A-diglycidyl-ether (BADGE) in canned fish in oil. Food Additives & Contaminants, 16(5), 189-195. https://doi.org/10.1080/026520399284055
CR  - Szczepańska, N., Kudłak, B., & Namieśnik, J. (2018). Assessing ecotoxicity and the endocrine potential of selected phthalates, BADGE and BFDGE derivatives in relation to environmentally detectable levels. Science of the Total Environment, 610, 854 866. https://doi.org/10.1016/j.scitotenv.2017.08.160
CR  - Tato, T., Salgueiro-González, N., León, V.M., González, S., & Beiras, R. (2018). Ecotoxicological evaluation of the risk posed by bisphenol A, triclosan, and 4-nonylphenol in coastal waters using early life stages of marine organisms (Isochrysis galbana, Mytilus galloprovincialis, Paracentrotus lividus, and Acartia clausi). Environmental Pollution, 232, 173-182. https://doi.org/10.1016/j.envpol.2017.09.031
CR  - Wang, L., Liao, C., Liu, F., Wu, Q., Guo, Y., Moon, H.B., & Kannan, K. (2012). Occurrence and human exposure of p-hydroxybenzoic acid esters (parabens), bisphenol A diglycidyl ether (BADGE), and their hydrolysis products in indoor dust from the United States and three East Asian countries. Environmental Science & Technology, 46(21), 11584-11593. https://doi.org/10.1021/es303516u
CR  - Wang, D., Zhao, H., Fei, X., Synder, S.A., Fang, M., & Liu, M. (2021). A comprehensive review on the analytical method, occurrence, transformation and toxicity of a reactive pollutant: BADGE. Environment International, 155, 106701. https://doi.org/10.1016/j.envint.2021.106701
CR  - Wu, N.C., & Seebacher, F. (2020). Effect of the plastic pollutant bisphenol A on the biology of aquatic organisms: A meta-analysis. Global Change Biology, 26(7), 3821-3833. https://doi.org/10.1111/gcb.15127
CR  - Xiang, R., Shi, J., Yu, Y., Zhang, H., Dong, C., Yang, Y., & Wu, Z. (2018). The effect of bisphenol A on growth, morphology, lipid peroxidation, antioxidant enzyme activity, and PS II in Cylindrospermopsis raciborskii and Scenedesmus quadricauda. Archives of Environmental Contamination and Toxicology, 74, 515 526. https://doi.org/10.1007/s00244-017-0454-1
CR  - Xie, J., Zhao, N., Zhang, Y., Hu, H., Zhao, M., & Jin, H. (2022). Occurrence and partitioning of bisphenol analogues, triclocarban, and triclosan in seawater and sediment from East China Sea. Chemosphere, 287, 132218. https://doi.org/10.1016/j.chemosphere.2021.132218
CR  - Xing, J., Zhang, S., Zhang, M., & Hou, J. (2022). A critical review of presence, removal and potential impacts of endocrine disruptors bisphenol A. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology, 254, 109275. https://doi.org/10.1016/j.cbpc.2022.109275
UR  - https://doi.org/10.12714/egejfas.41.3.05
L1  - https://dergipark.org.tr/tr/download/article-file/3965776
ER  -