TY - JOUR T1 - Dosimetric Investigation of Acetaminophen Drug Raw Materials by Electron Paramgangnetic Resonance Spectroscopy TT - Acetaminophen İlaç Hammaddelerinin Elektron Paramanyetik Rezonans Spektroskopisi ile Dozimetrik İncelenmesi AU - Akbalık, Fırat PY - 2024 DA - December Y2 - 2024 DO - 10.5281/zenodo.14344267 JF - Journal of Anatolian Physics and Astronomy JO - Journal of Anatolian Physics and Astronomy PB - Atatürk Üniversitesi WT - DergiPark SN - 2791-8718 SP - 75 EP - 82 VL - 3 IS - 2 LA - en AB - In the present study, the active pharmaceutical ingredient Acetaminophen, which is used in the treatment of moderate pain, chemotherapy and relief of postoperative pain, was exposed to gamma radiation and the resulting paramagnetic disorder was studied by Electron Paramagnetic Resonance (EPR) spectroscopy. The suitability of the drug sample for use as a dosimetric material, radical extinction data, saturation information occurring at microwave power values and parameters related to dose-response data were investigated at room temperature. No EPR signal was observed in the sample which was not exposed to gamma radiation. Spectroscopic properties generated as a result of radiation were determined via spectrum simulation. KW - Dosimetry KW - Gamma Radiation KW - Drug sample KW - EPR KW - Radicals KW - Irradiated N2 - Bu çalışmada genellikle orta seviyedeki ağrıların tedavisinde kullanılmasına rağmen ameliyat sonrası ağrıların şiddetlerinin azaltılmasında ve kanser hastalarında kemoterapi amacı ile de kullanıldığı bilinen ilaç etkin maddesi Acetaminophen toz kristalleri gama radyasyonuna maruz bırakılarak oluşan paramanyetik bozukluk Elektron Paramanyetik Rezonans (EPR) spektroskopisi ile çalışılmıştır. Örneğin dozimetrik malzeme olarak kullanıma uygunluğu, radikal sönüm bilgileri, mikrodalga güç değerlerinde doyum bilgileri ve doz-cevap eğrisi oda sıcaklığında araştırılmıştır. Gama radyasyonuna maruz bırakılmayan örnekte EPR sinyali gözlenmemiştir. Spektrum simülasyonu (benzetişimi) yapılarak radyasyon sonucunda oluşan spektroskopik özellikleri belirlenmiştir. CR - Abbar, J. C., Lamani, S. D., & Nandibewoor, S. T. (2011). Ruthenium(III) Catalyzed Oxidative Degradation of Amitriptyline-A Tricyclic Antidepressant Drug by Permanganate in Aqueous Acidic Medium. Journal of Solution Chemistry, 40(3), 502–520. https://doi.org/10.1007/s10953-011-9655-9 CR - Akbalık, F. (2016). Analysis of structural defects caused by gamma radiation on some medicines through electron paramagnetic resonance and simulation techniques. PhD thesis, Dicle University. CR - Basly, J., & Bernard, M. (1997). 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