TY  - JOUR
T1  - Evaluation of Antioxidant, Cytotoxic Effects and Phytochemical Profiles of Galls Caused by Eriophyidae mite in Juglans regia Leaves
AU  - Bulut, Semih
AU  - Özüpek, Burçin
AU  - Pekacar, Sultan
AU  - Özdemir, Aysun
AU  - Deliorman Orhan, Didem
PY  - 2024
DA  - October
Y2  - 2024
DO  - 10.55262/fabadeczacilik.1511498
JF  - Fabad Eczacılık Bilimler Dergisi
JO  - Fabad J Pharm Sci
PB  - FABAD Ankara Eczacılık Bilimleri Derneği
WT  - DergiPark
SN  - 1300-4182
SP  - 525
EP  - 538
VL  - 49
IS  - 3
LA  - en
AB  - This research presents the first study findings on the phytochemical contents and anticancer and antioxidant activities of galls caused by Eriophyidae mites on the leaves of Juglans regia L. Gall extracts collected from different localities in Turkey and prepared with solvents of different polarity were investigated for both antioxidant and cytotoxic activity. Cytotoxic activity studies showed that MCF-7 cancer cells were more sensitive to WLAA extract at a concentration of 100 µg/mL compared to healthy HUVEC cell lines. LC-QTOF-MS analysis results showed that all extracts contain chlorogenic acid, quercetin 4'-glucoside/quercetin 3-galactoside, quercetin 7-xyloside/quercetin 3-arabinoside, quercetin 7-rhamnoside, kaempferol 3-xyloside/kaempferol 3-O-arabinoside, and kaempferol derivatives. It was concluded that polyphenolic extracts obtained from galls formed in J. regia leaves can be considered as a new potential natural source for drug development studies due to their antioxidant and cytotoxic effects.
KW  - Antioxidant
KW  - cytotoxicity
KW  - galls
KW  - Juglans regia
KW  - phytochemical profile
CR  - Zongo, C., Savadogo, A., Ouattara, L., Bassole, I. H. N., Ouattara, C. A. T., Ouattara, A. S., . . . TraoreI, A. S. (2010). Polyphenols content, antioxidant and antimicrobial activities of Ampelocissus grantii (Baker) Planch.(Vitaceae): a medicinal plant from Burkina Faso. International Journal of Pharmacology, 6(6), 880–887. https://doi: 10.3923/ijp.2010.880.887
UR  - https://doi.org/10.55262/fabadeczacilik.1511498
L1  - https://dergipark.org.tr/tr/download/article-file/4049769
ER  -