TY  - JOUR
T1  - Dimethyl Fumarate Improves Detrusor Contractility in Streptozotocin-Induced Diabetic Rats
TT  - Dimetil Fumarat Streptozotosin ile Diyabet Oluşturulmuş Sıçanlarda Detrüsör Kontraktilitesini İyileştirir
AU  - Engin, Seçkin
AU  - Kaya Yaşar, Yeşim
AU  - Barut, Elif Nur
PY  - 2024
DA  - December
Y2  - 2024
DO  - 10.25048/tudod.1517395
JF  - Turkish Journal of Diabetes and Obesity
JO  - Turk J Diab Obes
PB  - Zonguldak Bülent Ecevit Üniversitesi
WT  - DergiPark
SN  - 2587-0335
SP  - 287
EP  - 293
VL  - 8
IS  - 3
LA  - en
AB  - Aim: The present study aimed to investigate potential effect of dimethyl fumarate (DMF) on bladder dysfunction in streptozotocin(STZ)-induced diabetic rats.Material and Methods: Adult male Sprague Dawley rats were given a single intraperitoneal dose of streptozotocin (60 mg/kg) to inducediabetes. After eight weeks, diabetic and nondiabetic rats were orally treated with DMF (25 or 100 mg/kg/day) or vehicle for four weeksorally. At 12 week after diabetes induction, in vitro organ bath studies were performed on detrusor strips of each rat and the contractileresponses to KCl and carbachol (CCh) of the strips were evaluated.Results: The maximal KCl (80 mM)- and CCh-induced contractile responses of detrusor strips significantly (p
KW  - Bladder
KW  - Carbachol
KW  - Contraction
KW  - Detrusor muscle
KW  - Diabetic complication
KW  - Dimethyl fumarate
KW  - Streptozotocin
N2  - potansiyel etkisi araştırıldı.Gereç ve Yöntemler: Yetişkin erkek Sprague Dawley sıçanlara diyabet indüksiyonu için tek doz intraperitoneal streptozotosin (60 mg/kg) verildi. Sekiz hafta sonra, diyabetik ve diyabetik olmayan sıçanlara dört hafta boyunca oral DMF (25 veya 100 mg/kg/gün) veyataşıyıcı tedavileri uygulandı. Diyabet indüksiyonundan 12 hafta sonra, her bir sıçanın detrüsör şeritleri üzerinde in vitro organ banyosuçalışmaları yapıldı ve şeritlerin KCl ve karbakol (CCh) ile indüklenen kasılma yanıtları değerlendirildi.Bulgular: Detrüsör şeritlerinin KCl (80 mM) ve CCh ile indüklenen maksimum kasılma yanıtları, diyabetik grupta (sırasıyla 84,35±13,56ve 178,80±29,66 mg gerim/mg doku) kontrol grubuna (sırasıyla 175,10±13,42 ve 399,40±77,63 mg gerim/mg doku) göre önemli ölçüdeazaldı (p
CR  - 1. Gomez CS, Kanagarajah P, Gousse AE. Bladder dysfunction in
patients with diabetes. Curr Urol Rep. 2011;12(6):419-426.
CR  - 2. Panigrahy R, Singh B, Das SK. Diabetic uropathy and bladder
dysfunctions. Diabetes Metab Syndr. 2017;11(1):81-82.
CR  - 3. Erdogan BR, Liu G, Arioglu-Inan E, Michel MC. Established
and emerging treatments for diabetes-associated lower urinary
tract dysfunction. Naunyn Schmiedebergs Arch Pharmacol.
2022;395(8):887-906.
CR  - 4. Bolgeo T, Maconi A, Bertolotti M, Roveta A, Betti M, Gatti D,
Boccafoschi C. Physiopathology of the diabetic bladder. Arch
Ital Urol Androl. 2020;92(4):10.4081/aiua.2020.4.314.
CR  - 5. Wittig L, Carlson KV, Andrews JM, Crump RT, Baverstock RJ.
Diabetic bladder dysfunction: A review. Urology. 2019;123:1-
6.
CR  - 6. Beshay E, Carrier S. Oxidative stress plays a role in diabetes-
induced bladder dysfunction in a rat model. Urology.
2004;64(5):1062-1067.
CR  - 7. Saidu NEB, Kavian N, Leroy K, Jacob C, Nicco C, Batteux F,
Alexandre J. Dimethyl fumarate, a two-edged drug: Current
status and future directions. Med Res Rev. 2019;39(5):1923-
1952.
CR  - 8. Bresciani G, Manai F, Davinelli S, Tucci P, Saso L, Amadio
M. Novel potential pharmacological applications of dimethyl
fumarate-an overview and update. Front Pharmacol.
2023;14:1264842.
CR  - 9. He F, Ru X, Wen T. NRF2, a transcription factor for stress
response and beyond. Int J Mol Sci. 2020;21(13):4777.
CR  - 10. Dodson M, Shakya A, Anandhan A, Chen J, Garcia JGN,
Zhang DD. NRF2 and diabetes: The good, the bad, and the
complex. Diabetes. 2022;71(12):2463-2476.
CR  - 11. Wu J, Sun X, Jiang Z, Jiang J, Xu L, Tian A, Sun X, Meng
H, Li Y, Huang W, Jia Y, Wu H. Protective role of NRF2 in
macrovascular complications of diabetes. J Cell Mol Med.
2020;24(16):8903-8917.
CR  - 12. Zhou S, Jin J, Bai T, Sachleben LR Jr, Cai L, Zheng Y. Potential
drugs which activate nuclear factor E2-related factor 2 signaling
to prevent diabetic cardiovascular complications: A focus
on fumaric acid esters. Life Sci. 2015;134:56-62.
CR  - 13. Özenoğlu S, Turan İ, Sayan Özaçmak H, Özaçmak VH.
Deneysel diyabet oluşturulan sıçanlarda kalp ve iskelet kası
Nrf2 yapımı ve oksidatif stres üzerine melatoninin etkisinin
incelenmesi. Turk J Diab Obes. 2020;4(1):46-53.
CR  - 14. Hu X, Rajesh M, Zhang J, Zhou S, Wang S, Sun J, Tan Y,
Zheng Y, Cai L. Protection by dimethyl fumarate against diabetic
cardiomyopathy in type 1 diabetic mice likely via activation
of nuclear factor erythroid-2 related factor 2. Toxicol Lett.
2018;287:131-141.
CR  - 15. Li Y, Ma F, Li H, Song Y, Zhang H, Jiang Z, Wu H. Dimethyl
fumarate accelerates wound healing under diabetic condition.
J Mol Endocrinol. 2018;61(4):163-172.
CR  - 16. Amin FM, Abdelaziz RR, Hamed MF, Nader MA, Shehatou
GSG. Dimethyl fumarate ameliorates diabetes-associated vascular
complications through ROS-TXNIP-NLRP3 inflammasome
pathway. Life Sci. 2020;256:117887.
CR  - 17. Dwivedi DK, Jena GB. Dimethyl fumarate-mediated Nrf2/
ARE pathway activation and glibenclamide-mediated NLRP3
inflammasome cascade inhibition alleviate type II diabetes-associated
fatty liver in rats by mitigating oxidative stress and
inflammation. J Biochem Mol Toxicol. 2023;37(7):e23357.
CR  - 18. Wang L, Sun W, Ren G, Sun Y, Xu C, Song Q, Zhang X, Yang
C, Liu Z. Deletion of Nrf2 induced severe oxidative stress and
apoptosis in mice model of diabetic bladder dysfunction. Int
Urol Nephrol. Published online May 21, 2024.
CR  - 19. Engin S, Yasar YK, Barut EN, Sezen SF. Improved endothelium-
dependent relaxation of thoracic aorta in
niclosamide-treated diabetic rats. Cardiovasc Toxicol.
2021;21(7):563-571.
CR  - 20. Casili G, Lanza M, Filippone A, Cucinotta L, Paterniti I, Repici
A, Capra AP, Cuzzocrea S, Esposito E, Campolo M. Dimethyl
fumarate (DMF) alleviated post-operative pain (PO) through
the N-Methyl-d-Aspartate (NMDA) receptors. Antioxidants
(Basel). 2022;11(9):1774.
CR  - 21. Singh J, Thapliyal S, Kumar A, Paul P, Kumar N, Bisht M,
Naithani M, Rao S, Handu SS. Dimethyl fumarate ameliorates
paclitaxel-induced neuropathic pain in rats. Cureus.
2022;14(9):e28818.
CR  - 22. Engin S, Kılıç M, Gazioğlu EN, Kadıoğlu Duman M. Effect of
trimebutine maleate on acetylcholine, potassium chloride and
adenosine triphosphate induced contractions of rat detrusor
smooth muscle. FABAD J Pharm Sci. 2013; 38(2): 65-71.
CR  - 23. Çölgeçen AD, Sayan Özaçmak H. Glukagon benzeri peptit-1
reseptör agonisti liraglutidin sıçan detrüsor kas kasılma yanıtı
üzerine etkisi. Turk J Diab Obes. 2024;8(1):71-8.
CR  - 24. Engin S, Barut EN, Yaşar YK, Soysal AÇ, Arıcı T, Kerimoğlu
G, Kadıoğlu M, Sezen SF. Trimetazidine attenuates cyclophosphamide-
induced cystitis by inhibiting TLR4-mediated NFκB
signaling in mice. Life Sci. 2022;301:120590.
CR  - 25. Sun H, Saeedi P, Karuranga S, Pinkepank M, Ogurtsova K,
Duncan BB, Stein C, Basit A, Chan JCN, Mbanya JC, Pavkov
ME, Ramachandaran A, Wild SH, James S, Herman WH,
Zhang P, Bommer C, Kuo S, Boyko EJ, Magliano DJ. IDF Diabetes
Atlas: Global, regional and country-level diabetes prevalence
estimates for 2021 and projections for 2045. Diabetes
Res Clin Pract. 2022;183:109119.
CR  - 26. Yang XF, Wang J, Rui-Wang, Xu YF, Chen FJ, Tang LY, Ren
WK, Fu LJ, Tan B, Huang P, Cao HY. Time-dependent functional,
morphological, and molecular changes in diabetic
bladder dysfunction in streptozotocin-induced diabetic mice.
Neurourol Urodyn. 2019;38(5):1266-1277.
CR  - 27. Daneshgari F, Liu G, Birder L, Hanna-Mitchell AT, Chacko
S. Diabetic bladder dysfunction: current translational knowledge.
J Urol. 2009;182(6 Suppl):S18-S26.
CR  - 28. Song QX, Sun Y, Deng K, Mei JY, Chermansky CJ, Damaser
MS. Potential role of oxidative stress in the pathogenesis of
diabetic bladder dysfunction. Nat Rev Urol. 2022;19(10):581-
596.
CR  - 29. Ustuner MC, Kabay S, Ozden H, Guven G, Yucel M, Olgun
EG, Ustuner D, Unal N, Degirmenci I. The protective effects
of vitamin E on urinary bladder apoptosis and oxidative
stress in streptozotocin-induced diabetic rats. Urology.
2010;75(4):902-906.
CR  - 30. Fathollahi A, Daneshgari F, Hanna-Mitchell AT. Effect of
polyuria on bladder function in diabetics versus non-diabetics:
An article review. Curr Urol. 2015;8(3):119-125.
UR  - https://doi.org/10.25048/tudod.1517395
L1  - https://dergipark.org.tr/tr/download/article-file/4075879
ER  -