TY  - JOUR
T1  - Growth-Inhibitory Effects of Traditional Chemotherapeutic Combinations  (FOLFOX, FOLFIRI) on Colon Cancer Cells: An in vitro Study
TT  - Geleneksel Kemoterapötik Kombinasyonların (FOLFOX, FOLFIRI) Kolon Kanseri Hücreleri Üzerindeki Büyüme-Engelleyici Etkileri: Bir in vitro Çalışma
AU  - Yıldırım Kocaman, Aslı
AU  - Erden Tayhan, Seçil
PY  - 2024
DA  - December
Y2  - 2024
DO  - 10.26453/otjhs.1538781
JF  - Online Turkish Journal of Health Sciences
JO  - OTSBD
PB  - Oğuz KARABAY
WT  - DergiPark
SN  - 2459-1467
SP  - 349
EP  - 356
VL  - 9
IS  - 4
LA  - en
AB  - Objective: To compare the in vitro growth-inhibitory effects of the commonly used chemotherapeutic combinations folinic acid, 5-fluorouracil, and oxaliplatin (FOLFOX) and folinic acid, 5-fluorouracil, and irinotecan (FOLFIRI) on colon cancer cells (HT29 and CaCo-2 cells).Materials and Methods: The viability of HT29 and CaCo-2 cells treated with different concentrations of the FOLFOX and FOLFIRI combinations was evaluated using the MTT (3-(4,5-dimethylthiazolyl-2)-2,5-diphenyltetrazolium bromide) assay. Results: FOLFOX and FOLFIRI combinations exhibited varying effects on the colon cancer cell lines, with HT29 cells showing sensitivity, while CaCo-2 cells demonstrated resistance to these treatments.Conclusions: The results of this preliminary study will contribute to the development of effective and targeted clinical treatment strategies for colon cancer.
KW  - Colon cancer
KW  - drug combination
KW  - FOLFOX
KW  - FOLFIRI
KW  - growth-inhibitory effect
N2  - Amaç: Yaygın olarak kullanılan kemoterapötik kombinasyonlar olan folinik asit, 5-florourasil ve oksaliplatin (FOLFOX) ile folinik asit, 5-florourasil ve irinotekanın (FOLFIRI) kolon kanseri hücreleri (HT29 ve CaCo-2 hücreleri) üzerindeki in vitro büyümeyi inhibe edici etkilerini karşılaştırmak.Materyal ve Metot: FOLFOX ve FOLFIRI kombinasyonlarının farklı konsantrasyonlarıyla tedavi edilen HT29 ve CaCo-2 hücrelerinin canlılığı MTT (3-(4,5-dimetiltiazolil-2)-2,5-difeniltetrazolium bromür) testi kullanılarak değerlendirildi.Bulgular: FOLFOX ve FOLFIRI kombinasyonları kolon kanseri hücre hatları üzerinde farklı etkiler gösterdi, HT29 hücreleri duyarlılık gösterirken, CaCo-2 hücreleri bu tedavilere direnç gösterdi.Sonuç: Bu ön çalışmanın sonuçları, kolon kanseri için etkili ve hedefli klinik tedavi stratejilerinin geliştirilmesine katkıda bulunacaktır.
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UR  - https://doi.org/10.26453/otjhs.1538781
L1  - https://dergipark.org.tr/tr/download/article-file/4169880
ER  -