TY - JOUR T1 - Investigation of the Rational Antibiotic Uses of University Students AU - Aykemat, Yalçın AU - Yıldız Ayvaz, Meryem AU - Karadağ Aytemiz, Özge Eda AU - Urlu, Melike Merve AU - Kolaç, Pelin PY - 2025 DA - February Y2 - 2025 DO - 10.26650/CURARE.2025.1547521 JF - CURARE Journal of Nursing PB - İstanbul Üniversitesi WT - DergiPark SN - 2980-1133 SP - 1 EP - 8 IS - 7 LA - en AB - Objective: This study assessed university students’ knowledge levels regarding rational antibiotic use.Methods: This study sample comprised 105 students studying at a university in Istanbul. The students were enrolled across five different faculties. The data were collected using an information form developed by the researchers. The parameters of the normal distribution were determined using the Shapiro-Wilk test. The Student’s t-test was applied to evaluate the normally distributed quantitative data between the two groups. Mann–Whitney U test was used for data that was not normally distributed. The chi-square test, Continuity (Yates) Correction, and Fisher exact chi-square tests were used to compare the qualitative data.Results: The largest proportion of participants were health science faculty students (38.6%). Most students had previously received information about antibiotic use (71.0%), had used antibiotics before (91.7%), read the package insert before using antibiotics (72.4%), made an effort to take antibiotics on time (79.3%), lacked understanding of the term microbiota (59.3%), and lacked knowledge about the relationship between antibiotics and microbiota (55.9%).Conclusion: The findings indicate that most students adhered to the principles of rational antibiotic use. The students required information about the human microbiota and the relationship between microbiota and antibiotics. Comprehensive educational programs should be implemented to improve students’ understanding of rational antibiotic use and its relationship with the microbiota. KW - Rational use of antibiotics KW - microbiota KW - university students CR - 1 Esin MN, Bulduk S, Dural Ç, Şenolan G, Temel E. Medication-related behaviors of adult individuals. Florence Nightingale Journal af Nursing. 2014; 15(60):139-145. google scholar CR - 2 Karahocagil MK, Er A, Kırıkçı AD, Sünnetçioğlu M, Yapıcı K, Bilici A, et al. İnvestigation of antibiotic use in inpatients at Yüzüncü Yıl University Faculty of Medicine Research Hospital. VTD. 2007; 14(2):46-51. google scholar CR - 3 Khan FU, Khan FU, Hayat K, Ahmad T, Khan A, Chang J, et al. Knowledge, attitude, and practice on antibiotics and its resistance: A two-phase mixed-methods online study among Pakistani community pharmacists to promote rational antibiotic use. International Journal of Environmental Research and Public Health. 2021;18(3):1320. https://doi.org/10.3390/ijerph18031320 google scholar CR - 4 Karaman A, Ayoğlu T, Aydoğan MN, Kuğu E. Rational drug usage status of nursing students. Florence Nightingale Journal of Nursing. 2019;27(2):143-156. google scholar CR - 5 Topal M, Uslu Şenel G, Arslan Topal Eİ, Öbek E. Antibiotics and their areas of use. Science Journal. 2015;31(3):121-127. google scholar CR - 6 Browne AJ, Chipeta MG, Haines-Woodhouse G, et al. Global antibiotic consumption and usage in humans, 2000-2018: A spatial modeling study. The Lancet Planetary Health. 2021;5(12):e893-e904. https://doi.org/10.1016/S2542-5196(21)00280-1 google scholar CR - 7 Samore MH, Bateman K, Alder SC, Hannah E, Donnelly S, Gregory JS, et al. Clinical decision support and appropriateness of antimicrobial prescribing. JAMA. 2005;294(18):2305. https://doi.org/10.1001/jama.294.18.2305 google scholar CR - 8 Aykan ŞB, Çiftci İH. Antibiotic resistance of Escherichia coli strains isolated from urine cultures in Turkey: A meta-analysis. Microbiology Bulletin. 2013;47(4):603-618. https://www.mikrobiyolbul.org/managete/fu folder/2013-04f2013-47-4-603-618.pdf google scholar CR - 9 Davies J, Davies D. Origins and evolution of antibiotic resistance. Microbiology and Molecular Biology Reviews. 2010;74(3): 417-433. https://doi.org/10.1128/ MMBR.00016-10 google scholar CR - 10 Munita JM, Arias CA. Mechanisms of antibiotic resistance. Microbiology Spectrum. 2016;4(2). https://doi.org/10.1128/microbiolspec.VMBF-0016-2015 google scholar CR - 11 Westerling R, Daryani A, Gershuni O, Czabanowska K. Promoting rational antibiotic use in Turkey and among Turkish migrants in Europe: İmplications of a qualitative study in four countries. Global Health. 2020;16(1):108. https://doi. org/10.1186/s12992-020-00637-5 google scholar CR - 12 Dodds DR. Antibiotic resistance: A current epilogue. Biochemical Pharmacology. 2017;134:139-146. https://doi.org/10.1016/j.bcp.2016.12.005 google scholar CR - 13 Yılmaztürk A. Rational drug use in Turkey and around the world. KUİBF Journal. 2013; 2(2):42-49. google scholar CR - 14 Dominguez-Bello MG, Godoy-Vitorino, Knight R, Blaser MJ. Role of the microbiome in human development. Gut. 2019;68(6):1108-1114. https://doi.org/ 10.1136/gutjnl-2018-317503 google scholar CR - 15 El-Sayed A, Aleya L, Kamel M. Microbiota’s role in health and diseases. Environmental Science and Pollution Research. 2021;28(28):36967-36983. https://doi.org/10.1007/s11356-021-14593-z google scholar CR - 16 Schwartz DJ, Langdon AE, Dantas G. Understanding the impact of antibiotic perturbation on the human microbiome. Genome Medicine. 2020;12(1):82. https://doi.org/10.1186/s13073-020-00782-x google scholar CR - 17 Kim S, Covington A, Pamer EG. The intestinal microbiota: Antibiotics, colonization resistance, and enteric pathogens. Immunological Reviews. 2017;279(1):90-105. https://doi.org/10.1111/imr.12563 google scholar CR - 18 Zimmermann P, Curtis N. The effect of antibiotics on the composition of the intestinal microbiota: A systematic review. Journal of Infection. 2019;79(6):471-489. https://doi.org/10.1016/j.jinf.2019.10.008 google scholar CR - 19 Şahin E, Dayıoğlu N, Ökmen B, Korkmaz E, Baykara Ş, Baktır G. Rational drug use awareness in university students training outside of health area and health area. Experimed. 2019;9(1):32-38. google scholar CR - 20 Saleem Z, Saeed H, Ahmad M, Yousaf M, Hassan HB, Javed A. Antibiotic self-prescribing trends, experiences and attitudes in upper respiratory tract infection among pharmacy and non-pharmacy students: A study from Lahore. PLoS One. 2016;11(2):e0149929. https://doi.org/10.1371/journal.pone.0149929 google scholar CR - 21 Ercan T, Biçer DF. Evaluation of factors affecting consumer knowledge levels and behaviors in rational drug use: The case of Sivas Province. Business & Management Studies: An International Journal. 201;7(2):998-1021. https://doi. org/10.15295/bmij.v7i2.1133 google scholar CR - 22 Akman N. A study on the knowledge and attitudes regarding antibiotic usage of health program. Turkish Microbiological Society Journal. 2021. https://doi.org/ 10.5222/TMCD.2021.04934 google scholar CR - 23 Shahpawee NS, Chaw LL, Muharram SH, Goh HP, Hussain Z, Ming LC. University students’ antibiotic use and knowledge of antimicrobial resistance: What are the common myths? Antibiotics. 2020;9(6):349. https://doi.org/10.3390/ antibiotics9060349 google scholar CR - 24 Kocyigit H, Akgoz AB, Bolat SM, Baykan Z. Evaluation of the knowledge, attitudes and behaviours of the first-year medical students at Erciyes University about rational antibiotic usage. Klimik Journal. 2020;33(1):29-35. https://doi.org/10. 5152/kd.2020.06 google scholar CR - 25 Büyüker SM. Evaluation of knowledge, attitudes, and practices regarding rational antibiotic use among midwifery students in the faculty of health sciences. Journal of AMR. 2020;5(2):11-16. google scholar CR - 26 Soysal A, Şahin E. Rational drug use: A study on university students. SAD. 2020;7(3): 175-182. google scholar CR - 27 Uçman T, Uysal N. Rational drug use and its influencing factors in adults. Bandırma Onyedi Eylül University Journal of Health Science Research. 2021;3(2):126-133. https://doi.org/10.46413/boneyusbad.859525 google scholar CR - 28 Khan AK, Banu G, Reshma KK. Antibiotic resistance and usage—A survey on the knowledge, attitude, perceptions and practices among the medical students of a Southern Indian teaching hospital. Journal of Clinical and Diagnostic Research. 2013. https://doi.org/10.7860/JCDR/2013/6290.3230 google scholar CR - 29 Cikes M, Vrdoljak L, Buljan I, Mudnic I, Vukojevic K, Mikic IM. Students’ practices and knowledge on antimicrobial usage and resistance in Split, Croatia: The education of future prescribers. Microbial Drug Resistance. 2020;26(6):623-629. https://doi.org/10.1089/mdr.2019.0238 google scholar UR - https://doi.org/10.26650/CURARE.2025.1547521 L1 - https://dergipark.org.tr/tr/download/article-file/4204183 ER -