TY - JOUR T1 - Kurkumin Nanoyapı Temelli Sensör Kullanılarak Pestisit Malation’un Elektrokimyasal Tayini TT - Electrochemical Determination of Pesticide Malathion using Curcumin Nanostructure Based Sensor AU - Yaman, Yeşim Tuğçe AU - Abacı, Serdar PY - 2025 DA - October Y2 - 2025 DO - 10.35414/akufemubid.1548528 JF - Afyon Kocatepe Üniversitesi Fen Ve Mühendislik Bilimleri Dergisi PB - Afyon Kocatepe Üniversitesi WT - DergiPark SN - 2149-3367 SP - 1062 EP - 1071 VL - 25 IS - 5 LA - tr AB - Bu çalışma, organofosforlu pestisitin bir üyesi olan malation’un (MLT) doğrudan elektrokimyasal tayini için kurkumin nanoparçacık (Kur NP) modifiye kalem grafit elektrodun (KGE) geliştirilmesini ve uygulamasını içermektedir. Kur NP, geniş yüzey alanı, değiştirilebilir boyutları, seçici hedefleme, iyi biyouyumluluk ve yüksek kararlılık gibi öne çıkan özellikleri nedeniyle araştırmacıların dikkatini çeken bir nanomalzemedir. Bu nedenle, bu çalışmada, basit, hızlı ve hassas bir yöntemle Kur NP-KGE’nin üretimi gerçekleştirilerek MLT’nin doğrudan elektro tespiti için önerilmiştir. Modifiye elektrodun özelliklerini belirlemek için morfolojik ve elektrokimyasal karakterizasyon gerçekleştirilmiştir. Kur NP modifiye elektrodun elektrokatalitik özellikleri dönüşümlü voltametri kullanılarak kaydedilmiş ve bazı parametreler optimize edilmiştir. Seçilen koşullar altında, diferansiyel puls voltametrisi kullanılarak 0,001 ile 0,6 µM arasında geniş bir doğrusal derişim aralığı elde edilmiş ve gözlenebilme sınırı 0,6 nM olarak belirlenmiştir. Elde edilen sonuçlar, çalışmamızın pratik öneminin altını çizmiş ve MLT’nin hassas ve doğrudan elektrokimyasal tayini için alternatif bir yaklaşım sunmuştur. KW - Malation KW - Pestisit KW - Nanomalzeme KW - voltametri KW - elektrokimyasal tayin N2 - This study involves the development and application of a curcumin nanoparticle (Kur NP) modified pencil graphite electrode (PGE) for the direct electrochemical determination of malathion (MLT), a member of organophosphorus pesticide. Kur NP is a nanomaterial that has attracted the attention of researchers due to its prominent features such as large surface area, modifiable dimensions, selective targeting, good biocompatibility and high stability. Therefore, in this study, a simple, fast and sensitive method for the fabrication of Kur NP-KGE is proposed for the direct electro-detection of MLT. To determine properties of the modified electrode, morphological and electrochemical characterization was carried out. The electrocatalytic properties of the Cur NP modified electrode was recorded using cyclic voltammetry and some parameters were optimized. Under selected conditions, a wide linear concentration range was obtained from 0.001 to 0.6 µM and the detection limit was determined as 0.6 nM by using differential pulse voltammetry. The gathered results underlined the practical importance of our work and represented an alternative approach for the sensitive and direct electrochemical detection of MLT. CR - Aghoutane, Y., Diouf, A., Österlund, L., Bouchikhi, B., & El Bari, N. 2020. Development of a molecularly imprinted polymer electrochemical sensor and its application for sensitive detection and determination of malathion in olive fruits and oils. Bioelectrochemistry, 132, 107404. https://doi.org/10.1016/j.bioelechem.2019.107404 CR - Anjitha, R., Antony, A., Shilpa, O., Anupama, K. P., Mallikarjunaiah, S., & Gurushankara, H. P. 2020. Malathion induced cancer-linked gene expression in human lymphocytes. Environmental Research, 182, 109131. https://doi.org/10.1016/j.envres.2020.109131 CR - Bolat, G., & Abaci, S. 2018. 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