TY - JOUR T1 - Evaluation of Clinical and Laboratory Findings in Patients with Brucellosis TT - Brusellozlu Hastalarda Klinik ve Laboratuvar Bulgularının Değerlendirilmesi AU - Mumcu, Necati AU - Özdemir, Yusuf AU - Çivak, Melike AU - Damar, Nagehan AU - Özdemir, Meryem Şahin PY - 2025 DA - April Y2 - 2024 DO - 10.46332/aemj.1549183 JF - Ahi Evran Medical Journal JO - Ahi Evran Med J PB - Kırşehir Ahi Evran Üniversitesi WT - DergiPark SN - 2619-9203 SP - 51 EP - 61 VL - 9 IS - 1 LA - en AB - Purpose: The purpose of this study is to evaluate the demographic data, laboratory and clinical findings and organ involvement of patients diagnosed with brucellosis.Materials and Methods: The patients were divided into groups according to sex (female/male) and age (≤40 years/>40 years and ≤30 years, 31-44 years, 45-59 years, and ≥60 years).Results: A total of 238 patients were assessed. Among those, 57.5% (n=137) were male, and the mean age was 43.8±15.0 years. Arthralgia (93.7%, n=223), myalgia (84.9%, n=202), and fatigue (84.5%, n=201) were the most common clinical symptoms. In female patients, myalgia (92.1% vs. 79.6%, p=0.008), fatigue (92.1% vs. 78.8%, p=0.005), headache (38.6% vs. 25.5%, p=0.031), and nausea (32.7% vs. 13.9%, p=0.001) were more common, whereas loss of appetite (43.5% vs. 59.9%, p=0.013) was less common. Weight loss (48.0% vs. 34.3%, p=0.034) and sacroiliitis (13.2% vs. 5.0%, p=0.029) were more common, whereas spondylodiscitis (2.0% vs. 9.3%, p=0.039) was less common in younger patients (≤40 years). Weight loss was more common in the ≤30 age group compared to the 31-44 age (55.8% vs. 32.8%, p=0.013) and 45-69 age groups (55.8% vs. 35.3%, p=0.019). Fever was less common in the ≤30 age group compared to the 45-59 age group (32.7% vs. 54.1%, p=0.015). Conclusion: In endemic areas, brucellosis should be considered in the differential diagnosis of patients with arthralgia, myalgia, fatigue, leukopenia or leukocytosis, and elevated ESR and CRP. Patients ≤40 years with brucellosis should be evaluated for sacroiliitis, and patients >40 years should be evaluated for spondylodiscitis complications. KW - age KW - brucella KW - gender KW - sacroiliitis KW - spondylodiscitis N2 - Amaç: Bu çalışmanın amacı bruselloz tanısı konulan hastaların demografik verilerini, klinik ve laboratuvar bulgularını ve organ tutulumlarını değerlendirmektir.Araçlar ve Yöntem: Hastalar cinsiyete (kadın/erkek) ve yaşa (≤40 yıl/>40 yıl ve ≤30 yıl, 31-44 yıl, 45-59 yıl ve ≥60 yıl) göre gruplara ayrıldı.Bulgular: Toplam 238 hasta değerlendirildi. Bunların %57.5'i (n=137) erkekti ve yaş ortalaması 43.8±15.0 yıldı. En sık görülen klinik semptomlar artralji (%93.7, n=223), miyalji (%84.9, n=202) ve yorgunluk (%84.5, n=201) idi. Kadın hastalarda miyalji (%92.1'e karşı %79.6, p=0.008), yorgunluk (%92.1'e karşı %78.8, p=0.005), baş ağrısı (%38.6'ya karşı %25.5, p=0.031) ve bulantı (%32.7'ye karşı %13.9, p=0.001) daha yaygındı, iştahsızlık (%43.5'e karşı %59.9, p=0.013) ise daha az yaygındı. Daha genç hastalarda (≤40 yaş) kilo kaybı (%48.0'e karşı %34.3, p=0.034) ve sakroileit (%13.2'ye karşı %5.0, p=0.029) daha yaygındı, spondilodiskit (%2.0'ye karşı %9.3, p=0.039) ise daha az yaygındı. Kilo kaybı ≤30 yaş grubunda 31-44 yaş grubuna (55.8% - %32.8, p=0.013) ve 45-69 yaş grubuna (55.8% - %35.3, p=0.019) göre daha yaygındı. Ateş ≤30 yaş grubunda 45-59 yaş grubuna (32.7% - %54.1, p=0.015) göre daha az yaygındı.Sonuç: Endemik bölgelerde, artralji, miyalji, yorgunluk, lökopeni veya lökositoz ve yüksek ESR ve CRP'li hastaların ayırıcı tanısında bruselloz düşünülmelidir. 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