@article{article_1555804, title={Encapsulation of Some Flavonoid Mixtures Using Electrospinning Technique for Enhanced Bioactivity and Controlled Release Studies}, journal={Necmettin Erbakan Üniversitesi Fen ve Mühendislik Bilimleri Dergisi}, volume={7}, pages={141–152}, year={2025}, author={Algan, Deniz Tuğçe and Kocabaş, Erdal}, keywords={Antibakteriyel etki, Elektroeğirme, Flavonoid, Hesperidin, in vitro ilaç salım, Naringin, Rutin hidrat}, abstract={Polymer-based electrospun fibers were prepared using bioactive compounds derived from citrus fruits such as rutin hydrate, naringin and hesperidin. These flavonoids have various biological activities such as antioxidant, anti-inflammatory and anticancer. By increasing the bioavailability of flavonoids through the electrospinning technique, it is aimed to develop potential applications in different areas such as drug delivery systems, food packaging and cosmetic products. The distribution and release behaviors of flavonoids in the fiber matrix were determined by morphological and chemical characterization of the obtained fibers. At the same time, the antibacterial activity of nanofibers against Staphylococcus aureus (S. aureus) bacteria was evaluated. As a result of the study, in the dissolution analysis performed at intestinal pH (pH 7.4), the active ingredients of PLA-MIX fiber were released at a rate of 20-25% and PCL-MIX fiber at a rate of 21-28%. Antibacterial results showed that nanofibers caused more bacterial inhibition in a 45% PLA mixture. This study provides an important contribution to the evaluation of citrus wastes and the development of new-generation biomaterials.}, number={1}, publisher={Necmettin Erbakan Üniversitesi}, organization={Tübitak ve Necmettin Erbakan Üniversitesi}