TY  - JOUR
T1  - Changes in body composition and muscle strength in girls with idiopathic central precocious puberty during gonadotropin-releasing hormone agonist therapy
TT  - Gonadotropin salgılatıcı hormon agonisti tedavisi sırasında idiyopatik santral erken ergenlik dönemindeki kızlarda vücut kompozisyonunda ve kas gücünde meydana gelen değişiklikler
AU  - Donbaloğlu, Zeynep
AU  - Singin, Berna
AU  - Barsal Çetiner, Ebru
AU  - Bedel, Aynur
AU  - Aydın Behram, Bilge
AU  - Çetin, Kürşat
AU  - Tuhan, Hale
AU  - Parlak, Mesut
PY  - 2025
DA  - January
Y2  - 2024
DO  - 10.32322/jhsm.1557045
JF  - Journal of Health Sciences and Medicine
JO  - J Health Sci Med /JHSM /jhsm
PB  - MediHealth Academy Yayıncılık
WT  - DergiPark
SN  - 2636-8579
SP  - 63
EP  - 69
VL  - 8
IS  - 1
LA  - en
AB  - Aims: Our objective is to explore changes in body fat distribution and muscle strength among a cohort of girls with idiopathic central precocious puberty (ICPP) undergoing the gonadotropin-releasing hormone analogs (GnRHa) therapy.Methods: A total of 50 patients who were newly diagnosed with ICPP and treated with GnRHa were included in the study. Patients were investigated at baseline, 6th months and 12th months.Results: Body-mass index (BMI) standard deviation score (SDS) was similar throughout the treatment duration. The percentage of body fat (PBF) increased from 24.2±5.1% at the beginning to 26.3±5.3% at the 6th month and to 27.7±5.43% at the 12th month (p
KW  - Central precocious puberty
KW  - GnRHa therapy
KW  - body composition
KW  - lean body mass
KW  - muscle strength
N2  - Amaçlar: Amacımız, gonadotropin salgılatıcı hormon analogları (GnRHa) tedavisi gören idiyopatik santral erken ergenlik (ICPP) hastası kızlardan oluşan bir kohortta vücut yağ dağılımı ve kas gücündeki değişiklikleri incelemektir.Yöntemler: Çalışmaya yeni ICPP tanısı almış ve GnRHa ile tedavi edilen toplam 50 hasta dahil edildi. Hastalar başlangıçta, 6. ayda ve 12. ayda incelendi.Sonuçlar: Vücut kitle indeksi (VKİ) standart sapma skoru (SDS) tedavi süresi boyunca benzerdi. Vücut yağ yüzdesi (PBF) başlangıçta %24,2±5,1'den 6. ayda %26,3±5,3'e ve 12. ayda %27,7±5,43'e yükseldi (p
CR  - Siervogel RM, Demerath EW, Schubert C, et al. Puberty and body composition. Horm Res. 2003;60(Suppl 1):36-45.
CR  - Antoniazzi F, Zamboni G. Central precocious puberty: current treatment options. Paediatr Drugs. 2004;6(4):211-231.
CR  - Carel JC, Eugster EA, Rogol A, et al. Consensus statement on the use of gonadotropin-releasing hormone analogs in children. Pediatrics. 2009;123(4):e752-e762.
CR  - Donbaloğlu Z, Bedel A, Çetiner EB, et al. Effects of the gonadotropin-releasing hormone agonist therapy on growth and body mass index in girls with idiopathic central precocious puberty. Acta Endocrinol (Buchar). 2022;18(2):181-186.
CR  - Gatt I, Smith-Moore S, Steggles C, Loosemore M. The takei handheld dynamometer: An effective clinical outcome measure tool for hand and wrist function in boxing. Hand. 2018;13(3):319-324.
CR  - Kurtoglu S, Mazicioglu MM, Özturk A, Hatipoglu N, Cicek B, Ustunbas HB. Body fat reference curves for healthy Turkish children and adolescents. Eur J Pediatr. 2010;169(11):1329-1335.
CR  - Neyzi O, Bundak R, Gökçay G, et al. Reference values for weight, height, head circumference, and body-mass index in Turkish children. J Clin Res Pediatr Endocrinol. 2015;7(4):280-293.
CR  - Marshall WA, Tanner JM. Variations in pattern of pubertal changes in girls. Arch Dis Childhood. 1969;44(235):291-303.
CR  - Greulich WW, Pyle SI. Radiographic atlas of skeletal development of the hand and wrist. 2nd ed. Stanford (CA): Stanford University Press; 1959;50-250.
CR  - Bayley N, Pinneau SR. Tables for predicting adult height from skeletal age: revised for use with the Greulich-Pyle hand standards. J Pediatr. 1952;40(4):423-441.
CR  - Roche AF, Wainer H, Thissen D. The RWT method for the prediction of adult stature. Pediatrics. 1975;56(6):1027-1033.
CR  - Guo SS, Chumlea WC, Roche AF, Siervogel RM. Age- and maturity-related changes in body composition during adolescence into adulthood: the Fels longitudinal study. Int J Obes Relat Metab Disord. 1997;21(12):1167-75.
CR  - Warner JT, Cowan FJ, Dunstan FD, Gregory JW. The validity of body mass index for the assessment of adiposity in children with disease states. Ann Hum Biol. 1997;24(3):209-215.
CR  - Lazarus R, Baur L, Webb K, Blyth F. Body mass index in screening for adiposity in children and adolescents: systematic evaluation using receiver operating characteristic curves. Am J Clin Nutr. 1996;63(4):500-506.
CR  - Bereket A. A critical appraisal of the effect of gonadotropin-releasing hormon analog treatment on adult height of girls with central precocious puberty. J Clin Res Pediatr Endocrinol. 2017; 9(Suppl 2):33-48.
CR  - Weise M, Flor A, Barnes KM, Cutler GB Jr, Baron J. Determinants of growth during gonadotropin-releasing hormone analog therapy for precocious puberty. J Clin Endocrinol Metab. 2004; 89(1):103-107.
CR  - Palmert MR, Mansfield MJ, Crowley Jr WF, Crigler Jr JF, Crawford JD, Boepple PA. Is obesity an outcome of gonadotropin-releasing hormone agonist administration? Analysis of growth and body composition in 110 patients with central precocious puberty. J Clin Endocrinol Metab. 1999;84(12):4480-4488.
CR  - Boot AM, De Muinck Keizer-Schrama S, Pols HA, Krenning EP, Drop SL. Bone mineral density and body composition before and during treatment with gonadotropin-releasing hormone agonist in children with central precocious and early puberty. J Clin Endocrinol Metab. 1998;83(2):370-373.
CR  - Siervogel RM, Maynard LM, Wisemandle WA, et al. Annual changes in total body fat and fat-free mass in children from 8 to 18 years in relation to changes in body-mass index. The Fels longitudinal study. Ann N Y Acad Sci. 2000;904:420-423.
CR  - Van der Sluis IM, Boot AM, Krenning EP, Drop SL, de Muinck Keizer-Schrama SM. Longitudinal follow-up of bone density and body composition in children with precocious or early puberty before, during and after cessation of GnRH agonist therapy. J Clin Endocrinol Metab. 2002;87(2):506-512.
CR  - Wacharasindhu S, Petwijit T, Aroonparkmongkol S, Srivuthana S, Kingpetch K. Bone mineral density and body composition in Thai precocious puberty girls treated with GnRH agonist. J Med Assoc Thai. 2006;89(8):1194-1198.
CR  - Chiumello G, Brambilla P, Guarneri MP, Russo G, Manzoni P, Sgaramella P. Precocious puberty and body composition: effects of GnRH analog treatment. J Pediatr Endocrinol Metab. 2000; 13(Suppl 1):791-794.
CR  - Kamp GA, Manasco PK, Barnes KM, et al. Low growth hormone levels are related to increased body mass index and do not reflect impaired growth in luteinizing hormone-releasing hormone agonist-treated children with precocious puberty. J Clin Endocrinol Metab. 1991;72(2):301-307.
CR  - Mansfield MJ, Rudlin CR, Crigler JF Jr, et al. Changes in growth and serum growth hormone and plasma somatomedin-C levels during suppression of gonadal sex steroid secretion in girls with central precocious puberty. J Clin Endocrinol Metab. 1988;66(1): 3-9.
CR  - Arrigo T, De Luca F, Antoniazzi F, et al. Reduction of baseline body mass index under gonadotropin-suppressive therapy in girls with idiopathic precocious puberty. Eur J Endocrinol. 2004; 150(4):533-537.
CR  - Lebrethon MC, Bourguignon JP. Management of central isosexual precocity: diagnosis, treatment, outcome. Curr Opin Pediatr. 2000;12(4):394-399.
CR  - Lee SJ, Yang EM, Seo JY, Kim CJ. Effects of gonadotropin-releasing hormone agonist therapy on body mass index and height in girls with central precocious puberty. Chonnam Med J.                                                                                                       2012;48(1):27-31.
CR  - Feuillan PP, Jones JV, Barnes K, Oerter-Klein K, Cutler Jr GB. Reproductive axis after discontinuation of gonadotropin-releasing hormone analog treatment of girls with precocious puberty: long term follow-up comparing girls with hypothalamic hamartoma to those with idiopathic precocious puberty. J Clin Endocrinol Metab. 1999;84(1):44-49.
CR  - Wolters B, Lass N, Reinehr T. Treatment with gonadotropin-releasing hormone analogues: different impact on body weight in normal-weight and overweight children. Horm Res Paediatr. 2012;78(5-6):304-311.
CR  - Yang WJ, Ko KH, Lee KH, Hwang IT, Oh YJ. The different effects of gonadotropin-releasing hormone agonist therapy on body mass index and growth between normal-weight and overweight girls with central precocious puberty. Ann Pediatr Endocrinol Metab. 2017;22(1):49-54.
CR  - Aguiar AL, Couto-Silva AC, Vicente EJ, Freitas IC, Cruz T, Adan L. Weight evolution in girls treated for idiopathic central precocious puberty with GnRH analogues. J Pediatr Endocrinol Metab. 2006;19(11):1327-1034.
CR  - Foster DL, Nagatani S. Physiological perspectives on leptin as a regulator of reproduction: role in timing puberty. Biol Reprod. 1999;60(2):205-215.
CR  - Palmert MR, Radovick S, Boepple PA. Leptin levels in children with central precocious puberty. J Clin Endocrinol Metab. 1998; 83(7):2260-2265.
CR  - McMurray RG. Developmental exercise physiology. Med Amp Sci Sports Amp Exerc. 1996;28:1531.
CR  - Philippou A, Maridaki M, Halapas A, Koutsilieris M. The role of the insulin-like growth factor 1 (IGF-1) in skeletal muscle physiology. In Vivo. 2007;21(1):45-54.
CR  - Ozmun JC, Mikesky AE, Surburg PR. Neuromuscular adaptations following prepubescent strength training. Med Sci Sport Exer. 1994;26(4):510-514.
CR  - Costa T, Murara P, Vancini RL, de Lira CAB, Andrade MS. Influence of biological maturity on the muscular strength of young male and female swimmers. J Hum Kinet. 2021;78:67-77.
CR  - Beunen G, Malina RM. Growth and physical performance relative to timing of the adolescent spurt. Exerc Sport Sci Rev. 1988;16:503-540.
UR  - https://doi.org/10.32322/jhsm.1557045
L1  - https://dergipark.org.tr/tr/download/article-file/4245325
ER  -