TY  - JOUR
T1  - Nodular Lymphoid Hyperplasia of the Gastrointestinal Tract with Selective IgA Deficiency in an Adult Patient: A Case Report
TT  - Selektif IgA eksikliği Olan Erişkin Hastada Gastrointestinal Nodüler Lenfoid Hiperplazi: Olgu Sunumu
AU  - Aydın, Arzu Hazal
AU  - Ergin, Mustafa
AU  - Tas Ayçiçek, Seda
PY  - 2025
DA  - October
Y2  - 2025
DO  - 10.52827/hititmedj.1567949
JF  - Hitit Medical Journal
JO  - Hitit Medical Journal
PB  - Hitit Üniversitesi
WT  - DergiPark
SN  - 2687-4717
SP  - 461
EP  - 464
VL  - 7
IS  - 3
LA  - en
AB  - Nodular lymphoid hyperplasia of the gastrointestinal tract is a rare and benign condition which may accompany immunodeficiency. Although being benign, it carries risk for intestinal and extraintestinal lymphoma. There is no specific and definitive treatment for NLH. Thus, treatment is dependent on the management of the associated conditions.  Duodenal and terminal ileal biopsies from a 54-year-old woman with multiple mesenteric lymphadenopathy and gastrointestinal lymphoid hyperplasia revealed nodular lymphoid hyperplasia as well as a paucity of plasma cells.Based on histopathological findings and laboratory results, a diagnosis of selective IgA deficiency was made.It is important to evaluate patients with nodular lymphoid hyperplasia for additional histopathological findings due to the association with possible immune deficiency such as absence or scarcity of plasma cells.
KW  - selective IgA deficiency
KW  - nodular lymphoid hyperplasia
KW  - gastrointestinal tract
N2  - Gastrointestinal kanalın nodüler lenfoid hiperplazisi (NLH) nadir ve benign bir durum olup immün yetmezlikler ile ilişkili olabilir. Benign bir durum olmasına rağmen artmış intestinal ve ekstraintestinal lenfoma riski söz konusudur. NLH’nin tedavisi ilişkili durumların yönetimine bağlıdır. Multiple mezenterik lenfadenopati ve gastrointestinal traktta diffüz lenfoid hiperplazi tespit edilen 54 yaşında kadın hastada duodenal ve terminal ileum biyopsilerinde nodüler lenfoid hiperplazi yanı sıra plazma hücrelerinde belirgin azalma tespit edilmiştir.Histopatolojik bulgular ve laboratuvar sonuçları esas alınarak selektif IgA eksikliği tanısı almıştır. Gastrointestinal trakt biyopsilerinde nodüler lenfoid hiperplazi bulguları izlenen hastalarda ilişkili olabilecek antiteler açısından da değerlendirme önemlidir.
CR  - Elkholy S, Albitar A, Elfadel S, Farag A, Roshdy A. Diffuse Nodular Lymphoid hyperplasia with Selective IgA Deficiency Syndrome Presenting with Intestinal Lymphoma. MOJ Clin Med Case Rep 2016;4(5):116-118.
CR  - Albuquerque A. Nodular lymphoid hyperplasia in the gastrointestinal tract in adult patients: A review. World journal of gastrointestinal endoscopy 2014;6(11):534.
CR  - Khuroo MS, Khuroo NS, Khuroo MS. Diffuse duodenal nodular lymphoid hyperplasia: a large cohort of patients etiologically related to Helicobacter pylori infection. BMC Gastroenterology 2011;11:1-12.
CR  - Ward E, Wolfsen H. The non-inherited gastrointestinal polyposis syndromes. Alimentary pharmacology & therapeutics 2002;16(3):333-342.
CR  - Chiaramonte C, Glick SN. Nodular lymphoid hyperplasia of the small bowel complicated by jejunal lymphoma in a patient with common variable immune deficiency syndrome. AJR American journal of roentgenology 1994;163(5):1118-1119.
UR  - https://doi.org/10.52827/hititmedj.1567949
L1  - https://dergipark.org.tr/tr/download/article-file/4290890
ER  -