@article{article_1572365, title={PHENOLIC CONTENT AND ANTIBACTERIAL ACTIVITY OF COTA PESTALOZZAE BOISS. AERIAL PARTS}, journal={Journal of Faculty of Pharmacy of Ankara University}, volume={49}, pages={264–270}, year={2025}, DOI={10.33483/jfpau.1572365}, author={Yılmaz, Özge and Rızvanoğlu, Sunasibel and Bahadır Acıkara, Özlem}, keywords={Antibakteriyel aktivite, Asteraceae, Cota, fenolik asitler, flavonoitler, HPLC}, abstract={Objective: The genus Cota was once considered a subgenus of Anthemis but is now recognized as an independent genus. The species belonging to Cota, including several endemic to Turkey, have been less extensively studied in the literature than other plants in the Asteraceae family. The current study aimed to examine the phenolic content and antibacterial activity of C. pestalozzae Boiss., an endemic species from Turkey.
Material and Method: The phenolic content of the methanol extract prepared from the aerial parts of C. pestalozzae Boiss. was analysed qualitatively and quantitatively using high-performance liquid chromatography (HPLC) analysis. This study calculated the limit of detection (LOD) and quantification (LOQ) for each detected compound. The antibacterial activity of the extract was also investigated against some Gram (+) and (-) bacteria strains. Result and Discussion: In the current study, chlorogenic acid, 4,5-O-dicaffeoyl quinic acid, 3,5-O-dicaffeoyl quinic acid, rutin, hyperoside and isoquercetin were qualitatively and quantitatively detected in the methanolic extract of the aerial parts of C. pestalozzae Boiss. Extract of the aerial parts exhibited antibacterial activity only against Staphylococcus aureus ATCC 43300 (MRSA) with a MIC value of 10000 µg/ml. The research indicates that C. pestalozzae contains phenolic compounds and is effective against Gram (+) bacteria.}, number={2}, publisher={Ankara Üniversitesi}