TY  - JOUR
T1  - Antifungal Activity of Ethanol Extract Desmanthus virgatus (L.) Leaves In Silico and In Vitro
AU  - Tukiran, Tukiran
AU  - Farkhiyah, Lilik
AU  - Dewistamara, Marshellia Ghinanda
PY  - 2025
DA  - August
Y2  - 2025
DO  - 10.55262/fabadeczacilik.1586787
JF  - Fabad Eczacılık Bilimler Dergisi
JO  - Fabad J Pharm Sci
PB  - FABAD Ankara Eczacılık Bilimleri Derneği
WT  - DergiPark
SN  - 1300-4182
SP  - 329
EP  - 342
VL  - 50
IS  - 2
LA  - en
AB  - Most fungal human infections are caused by Candida species, especially Candida albicans. C. albicans is a highly adaptable microorganism that can cause resistance after prolonged exposure to antifungals. C. albicans fungus is easily transmitted so that the discovery of new antifungal agents is very urgent. Therefore, this study aims to find antifungal agents from natural materials, namely wild tantan leaves in silico and in vitro. In the in silico test, 10 dominant compounds from LC-MS results using 2QZX protein obtained 3 compounds that have the most potential as antifungals with binding affinity values lower than ketoconazole. On the other hand, in the in vitro test with the agar diffusion method using disc paper, the average inhibition zone value was 0,01283 m and was classified as strong.
KW  - Antifungal
KW  - wild tantan
KW  - Candida albicans
KW  - in silico
KW  - in vitro
CR  - Aboody, M. S. Al, & Mickymaray, S. (2020). Antifungal efficacy and mechanisms of flavonoids. Antibiotics, 9(45), 1–42. https://doi.org/10.3390/antibiotics9020045 Andriana, F., Kumalasari, M. F., & Hadi, M. I. (2023). 
Aktivitas antifungi ekstrak daun kemangi (Ocimum basilicum L.) terhadap daya hambat Candida albicans secara in vitro pada kandidiasis. Scripta Biologica, 10(2), 1–5. https://doi.org/ 10.20884/1. SB.2023.10.2.1003
UR  - https://doi.org/10.55262/fabadeczacilik.1586787
L1  - https://dergipark.org.tr/tr/download/article-file/4373049
ER  -