TY - JOUR T1 - Relationship between Physical Activity, Hand Grip Strength, and Malnutrition Status in Neurodegenerative Diseases: A Case-Control Study TT - Relationship between Physical Activity, Hand Grip Strength, and Malnutrition Status in Neurodegenerative Diseases: A Case-Control Study AU - Sabuncular, Güleren AU - İslamoğlu, Ayşe Hümeyra AU - Bektaş, Şimal AU - Menevşe, İremnur AU - Taş, Sümeyra Nurcan AU - Aktaç, Şule PY - 2025 DA - May Y2 - 2025 DO - 10.30934/kusbed.1587855 JF - Kocaeli Üniversitesi Sağlık Bilimleri Dergisi JO - KOU Sag Bil Derg PB - Kocaeli Üniversitesi WT - DergiPark SN - 2149-8571 SP - 58 EP - 64 VL - 11 IS - 2 LA - en AB - Objective: To determine the relationship between physical activity level, hand grip asymmetry, and nutritional status in geriatric individuals with and without neurodegenerative diseases.Methods: This research was conducted in a nursing home in Istanbul between November 2023 and March 2024. The study included geriatric individuals aged 65 years and older with neurodegenerative diseases as the study group and age-matched controls with no evidence of neurodegeneration. Data collection involved sociodemographic surveys, anthropometric measurements, hand grip strength measurements, International Physical Activity Questionnaire and Mini Nutritional Assessment tests.Results: The mean age of study group was 76.7±7.3 and 74.3±7.5 years in control group. The study group had a higher malnutrition risk (59.3%) compared to controls, who showed predominantly normal nutritional status (66.7%, p=0.031). Hand grip strength measurements revealed greater asymmetry in the study group (74.1% vs. 33.3% with no asymmetry, p=0.003), along with significantly lower mean hand grip strength values on the right (13.3±6.4 vs. 22.1±7.6) and left hand (12.4±6.3 vs. 21.0±7.2, both p KW - geriatrics KW - neurodegenerative diseases KW - nutritional status KW - physical activity KW - handgrip strength N2 - Objective: To determine the relationship between physical activity level, hand grip asymmetry, and nutritional status in geriatric individuals with and without neurodegenerative diseases.Methods: This research was conducted in a nursing home in Istanbul between November 2023 and March 2024. The study included geriatric individuals aged 65 years and older with neurodegenerative diseases as the study group and age-matched controls with no evidence of neurodegeneration. Data collection involved sociodemographic surveys, anthropometric measurements, hand grip strength measurements, International Physical Activity Questionnaire and Mini Nutritional Assessment tests.Results: The mean age of study group was 76.7±7.3 and 74.3±7.5 years in control group. The study group had a higher malnutrition risk (59.3%) compared to controls, who showed predominantly normal nutritional status (66.7%, p=0.031). Hand grip strength measurements revealed greater asymmetry in the study group (74.1% vs. 33.3% with no asymmetry, p=0.003), along with significantly lower mean hand grip strength values on the right (13.3±6.4 vs. 22.1±7.6) and left hand (12.4±6.3 vs. 21.0±7.2, both p CR - Türkiye İstatistik Kurumu (TÜİK). İstatistiklerle yaşlılar. https://data.tuik.gov.tr/Bulten/Index?p=Istatistiklerle-Yaslilar-2022-49667 Accessed December 10, 2023. CR - Tieland M, Trouwborst I, Clark BC. Skeletal muscle performance and ageing. J Cachexia Sarcopenia Muscle. 2018;9(1):3-19. doi:10.1002/jcsm.12238 CR - Kuspinar A, Verschoor CP, Beauchamp MK, et al. Modifiable factors related to life-space mobility in community-dwelling older adults: Results from the Canadian Longitudinal Study on Aging. BMC Geriatr. 2020;20(1):35. doi:10.1186/s12877-020- 1432-2 CR - Alanazi MA. The role of physical activity in adjunctive nursing management of neuro-degenerative diseases among older adults: A systematic review of interventional studies. Life (Basel). 2024;14(5):597. doi:10.3390/life14050597 CR - Villemagne VL, Burnham S, Bourgeat P, et al. Amyloid β deposition, neurodegeneration, and cognitive decline in sporadic Alzheimer’s disease: A prospective cohort study. Lancet Neurol. 2013;12(4):357-367. doi:10.1016/S1474-4422(13)70045-3 CR - Keleş E, Özalevli S. Alzheimer’s Disease and Treatment Approaches. İzmir Katip Çelebi Univ Fac Health Sci J. 2018;3(2):39-42. CR - Camargo EC, Weinstein G, Beiser AS, et al. Association of physical function with clinical and subclinical brain disease: The Framingham Offspring Study. J Alzheimers Dis. 2016;53(4):1597-1608. doi:10.3233/JAD-160222 CR - Cin A, Boyraz S, Öztürk V, Yaka E. Malnutrition in old patients with stroke. Turk J Cerebrovasc Dis. 2019;25(3):155-163. CR - Yılmaz G, Karaca KE. Evaluation of the Nutritional Status of Geriatric Individuals with and without Dementia. Turk J Family Med Prim Care. 2021;15(3). doi:10.21763/tjfmpc.883284 Cruz-Jentoft AJ, Bahat G, Bauer J, et al. Sarcopenia: Revised European consensus on definition and diagnosis (EWGSOP2). Age Ageing. 2019;48(1):16-31. doi:10.1093/ageing/afy169 CR - Carson RG. Grip strength: Individual differences in the brain health marker. Neurobiol Aging. 2018;71:189-222. doi:10.1016/j.neurobiolaging.2018.07.004 CR - McGrath R, Johnson N, Klawitter L, et al. What are the association patterns between handgrip strength and adverse health conditions? A topical review. SAGE Open Med. 2020;8:2050312120910358. doi:10.1177/2050312120910358 CR - Lohman TG, Roche AF, Martorell R. Anthropometric Standardization Reference Manual. Champaign, IL: Human Kinetics Books; 1988. CR - Vaishya R, Misra A, Vaish A, et al. Hand grip strength as a proposed new vital sign of health: A narrative review of evidences. J Health Popul Nutr. 2024;43:7. doi:10.1186/s41043-024-00500-y CR - Aksu S, Çaman T, Özdemir İ, Bek S, Kutlu G. Lower handgrip strength in short-sleeper individuals with obstructive sleep apnea. Sleep Med. 2023;112:352-358. CR - Chen Z, Ho M, Chau PH. Handgrip strength asymmetry is associated with the risk of neurodegenerative disorders among Chinese older adults. J Cachexia Sarcopenia Muscle. 2022;13(2):1013-1023. doi:10.1002/jcsm.12867 CR - Saglam M, Arikan H, Savci S, et al. International physical activity questionnaire: reliability and validity of the Turkish version. Percept Mot Skills. 2010;111(1):278-284. doi:10.2466/06.08.PMS.111.4.278-2 CR - Craig CL, Marshall AL, Sjöström M, et al. International physical activity questionnaire: 12-country reliability and validity. Med Sci Sports Exerc. 2003;35(8):1381-1395. doi:10.1249/01.MSS.0000078924.61453.FB CR - Sarikaya D, Halil M, Kuyumcu ME, et al. Mini nutritional assessment test long and short form are valid screening tools in Turkish older adults. Arch Gerontol Geriatr. 2015;61(1):56-60. doi:10.1016/j.archger.2015.04.006 CR - Cohen J. Statistical Power Analysis for the Behavioral Sciences. 2nd ed. Hillsdale, NJ: Lawrence Erlbaum Associates; 1988. CR - Choi JY, Lee S, Min JY, Min KB. Asymmetrical handgrip strength is associated with lower cognitive performance in the elderly. J Clin Med. 2022;11(10):2904. doi:10.3390/jcm11102904 CR - Nasios G, Messinis L, Dardiotis E, Kassubek J. Communication, feeding, and swallowing disorders in neurological diseases. Behav Neurol. 2022;2022:9851424. doi:10.1155/2022/9851424 CR - Yalçın E, Rakıcıoğlu N. The Relationship between Handgrip Strength and Health in Elderly. J Nutr Diet. 2018;46(1):77-83. CR - Galesi LF, Leandro‐Merhi VA, de Oliveira MRM. Association between indicators of dementia and nutritional status in institutionalised older people. Int J Older People Nurs. 2012;8(3):236-243. doi:10.1111/opn.12011 CR - Brigola AG, Rossetti ES, Dos Santos BR, et al. Relationship between cognition and frailty in elderly: A systematic review. Dement Neuropsychol. 2015;9:110-119. CR - Chang M, Geirsdottir OG, Eymundsdottir H, et al. Association between baseline handgrip strength and cognitive function assessed before and after a 12-week resistance exercise intervention among community-living older adults. Aging Health Res. 2022;2(3):100092. doi:10.1016/j.ahr.2022.100092 UR - https://doi.org/10.30934/kusbed.1587855 L1 - https://dergipark.org.tr/tr/download/article-file/4377851 ER -