@article{article_1588776, title={Effect of Prenatal Magnesium Sulphate on Hearing Function in Premature Newborns}, journal={Jinekoloji-Obstetrik ve Neonatoloji Tıp Dergisi}, volume={22}, pages={241–246}, year={2025}, DOI={10.38136/jgon.1588776}, author={Kurt, Dilara Sarıkaya and Oğuz, Yüksel and Ulusoy, Can Ozan and Kurt, Ahmet and Kından, Aziz and Ağaoğlu, Recep Taha and Yakut Yücel, Kadriye}, keywords={Magnezyum Sülfat (MgSO4), Antenatal Nöroproteksiyon, Prematüre Yenidoğan, Sensorinöral İşitme Kaybı}, abstract={Objective: The study aimed to evaluate the potential neuroprotective effects of antenatal magnesium sulfate (MgSO4) on sensorineural hearing and auditory nerve development in premature newborns. Methods: This retrospective study included premature newborns ( <37 weeks) born between November 1, 2022, and December 31, 2023, at Etlik City Hospital. Newborns were divided into two groups: those exposed to antenatal MgSO4 (study group, n=40) and those unexposed (control group, n=126). Antenatal MgSO4 was administered at 2 grams/hour for at least 8 hours after a 6-gram loading dose. Hearing screening was conducted using auditory brainstem response (ABR) tests within the first month after birth. Maternal and neonatal characteristics, including gestational age, birthweight, and Apgar scores, were analyzed. Statistical comparisons between groups were performed using appropriate tests, with a significance level of p <0.05. Results: The failure rate in hearing screening tests did not significantly differ between the MgSO4 group (10%) and the control group (6.3%) (p=0.437). However, the MgSO4 group had lower gestational age at birth (median: 30.0 vs. 34.0 weeks, p <0.001), lower birthweight (median: 1424 vs. 2325 grams, p <0.001), and higher rates of Apgar scores below 7 at both the 1st and 5th minutes. Placental abruption, retinopathy of prematurity, and bronchopulmonary dysplasia were associated with hearing abnormalities in the overall cohort. Conclusion: Antenatal MgSO4 administration did not demonstrate a significant protective effect against hearing impairment in premature newborns. Larger prospective studies are warranted to clarify MgSO4’s role in auditory neuroprotection.}, number={3}, publisher={T.C. Sağlık Bakanlığı Ankara Şehir Hastanesi}