@article{article_1590697, title={SILVER NANOCOMPOSITES: A GLIMPSE INTO THEIR GAME-CHANGING ROLES IN ANTIBACTERIAL THERAPY}, journal={Journal of Faculty of Pharmacy of Ankara University}, volume={49}, pages={981–998}, year={2025}, DOI={10.33483/jfpau.1590697}, author={Yahya, Maimonah Q. and Khalil, Raghad Riyadh and Mohammed, Eman Tareq}, keywords={Antibakteriyel aktivite, antibiyotik, gümüş nanokompozitler, sinerjik etki}, abstract={Objective: The application of nanocomposites in biomedicine is a promising approach that scientists have discovered to eradicate infection-causing microorganisms properly and safely. Silver nanocomposites (AgNCs) can be recognized as hopeful antibacterial prospects that can fight both in vivo and in vitro infection-causing bacteria. The purpose of this review is to identify the variables that influence the antibacterial effect of AgNCs, given the pressing need for new, effective antibacterial agents.
Result and Discussion: In the literature, many reports indicate the capacity of AgNCs to combat both gram-positive and gram-negative bacteriomers, including those that are resistant to multiple drugs. This capacity is due to the multiple simultaneous modes of AgNCs action. This capacity also results in a synergistic impact on bacteria when mutually applied with natural or synthetic antibacterial medications. Because of their unique properties, AgNCs can be effectively used to manage or prevent infections in a variety of medical and healthcare products. The study focuses on the synthetic methodologies and antibacterial mechanisms of AgNCs. Furthermore, factors influencing the action of AgNCs against bacteriomers as well as the advantages of combining AgNCs with antibiotics to create novel antibacterial combinations were covered. The authors wanted to make it possible to reduce the dose required and prevent unfavorable off-target effects associated with both by providing access to the reviewed data.}, number={3}, publisher={Ankara Üniversitesi}