@article{article_1591976, title={Frontotemporal Dementia Associated with Behavioral and Psychotic Symptoms: Case Series}, journal={İzmir Tıp Fakültesi Dergisi}, volume={4}, pages={58–62}, year={2025}, DOI={10.57221/izmirtip.1591976}, author={Ergüner Aral, Ayşe and Erdogan, Esin}, keywords={psikotik bozukluk, frontotemporal demans, disinhibisyon, davranış değişikliği}, abstract={Frontotemporal Dementia Associated with Behavioral and Psychotic Symptoms: A Case Series Aim Frontotemporal dementia (FTD) is a subtype of degenerative dementia characterized by prominent impairments in personality, behavior, and cognition. This study aims to evaluate three cases presenting with acute psychotic symptoms who were later diagnosed with FTD, focusing on their behavioral and neuropsychiatric features. Cases The first case involves a 68-year-old woman with a 40-year history of schizophrenia. In recent years, she exhibited memory loss, disorganized behavior, and socially inappropriate actions. Neuroimaging revealed frontal and temporal atrophy. Despite antipsychotic treatment, disinhibition persisted. The second case is a 79-year-old woman who presented with memory impairment and psychotic symptoms. Neuroimaging demonstrated atrophy in the frontal and parietal lobes. Cognitive and behavioral symptoms did not improve despite treatment. The third case concerns an 85-year-old man presenting with disorganized behavior, psychotic symptoms, and progressive memory decline. Neuroimaging showed significant atrophy in the frontal and temporal lobes. While antipsychotic treatment reduced aggression, disinhibition persisted. Findings All three cases demonstrated disinhibition, disorganized behaviors, and cognitive deficits. Neuroimaging results indicated marked atrophy in the frontal and temporal lobes. The persistence of symptoms despite treatment supports the diagnosis of the behavioral variant of FTD. Discussion Before the diagnosis of FTD, the first case had recurrent episodes associated with schizophrenia, while no psychiatric diagnosis was present in the other two cases. In all three cases, disinhibition, disorganized behavior, and personality changes were predominant, aligning with the behavioral variant of FTD. The presentation of FTD with psychotic symptoms can be mistaken for other psychiatric disorders, complicating the diagnostic process. Cases with initial psychotic features but later diagnosed as FTD have been reported in the literature, emphasizing the need for careful use of antipsychotics. Conclusion Advanced imaging techniques and long-term neurocognitive monitoring play a crucial role in confirming the diagnosis of FTD and understanding its clinical course. Further research is needed to determine whether psychosis is a risk factor for FTD development.}, number={2}, publisher={Sağlık Bilimleri Üniversitesi}