TY  - JOUR
T1  - The structural effects of transcranial magnetic stimulation on hippocampal subfields in Alzheimer's disease
TT  - Alzheimer hastalığında transkraniyal manyetik stimülasyonun hipokampal alt alanlar üzerindeki yapısal etkileri
AU  - Velioglu, Halil Aziz
AU  - Sümbül Şekerci, Betül
AU  - Hanoğlu, Taha
AU  - Salar, Ali Behram
PY  - 2025
DA  - January
Y2  - 2024
DO  - 10.21673/anadoluklin.1595288
JF  - Anatolian Clinic the Journal of Medical Sciences
JO  - Anatolian Clin
PB  - Hayat Sağlık ve Sosyal Hizmetler Vakfı
WT  - DergiPark
SN  - 2149-5254
SP  - 62
EP  - 70
VL  - 30
IS  - 1
LA  - en
AB  - Aim: This study investigates the structural effects of repetitive transcranial magnetic stimulation (rTMS) on hippocampal subfields and cortical shape metrics in Alzheimer’s disease (AD) patients. Using high-resolution MRI segmentation and analysis via Hippunfold, we aim to elucidate TMS-induced structural changes and assess its potential neuroprotective role.Methods: This retrospective study included 17 AD patients and 18 healthy controls (HC). AD patients underwent 20 Hz rTMS targeting the left lateral parietal cortex over 10 sessions across two weeks. Magnetic resonance imaging (MRI) data were acquired before and after rTMS and analyzed with Hippunfold to segment hippocampal subfields and extract cortical thickness and shape metrics. Statistical analyses were performed to compare subfield volumes and cortical metrics between groups and across time points.Results: Hippocampal volumetric analysis revealed significant atrophy in subfields such as Cornu Ammonis 1, (CA1),  CA2, CA4, dentate gyrus (DG), subiculum, and stratum radiatum-lacunosum-moleculare (SRLM) in AD patients compared to HC. Although no significant volumetric recovery was observed post-TMS, a further decline was noted in the right CA3 subfield (p=0.005), highlighting progressive atrophy. Cortical shape analyses showed significant reductions in hippocampal thickness (p
KW  - Alzheimer’s disease
KW  - atrophy
KW  - hippokampus
KW  - transcranial magnetic stimulation
N2  - Amaç: Bu çalışma, Alzheimer hastalığı (AH) olan bireylerde tekrarlayan transkraniyal manyetik stimülasyonun (rTMS) hipokampal alt alanlar ve kortikal şekil metrikleri üzerindeki yapısal etkilerini araştırmaktadır. Yüksek çözünürlüklü MRI segmentasyonu ve Hippunfold analizi kullanılarak, TMS kaynaklı yapısal değişiklikleri incelemeyi ve TMS’nin olası nöroprotektif rolünü değerlendirmeyi amaçlıyoruz.Yöntemler: Bu retrospektif çalışmada, 17 AH hastası ve 18 sağlıklı kontrol (SK) yer aldı. AH hastalarına, iki hafta boyunca toplam 10 seanslık sol lateral paryetal korteksi hedefleyen 20 Hz rTMS uygulandı. Tedavi öncesi ve sonrası MRI görüntüleri Hippunfold yazılımıyla analiz edilerek hipokampal alt alanlar segmentlendi ve kortikal kalınlık ile şekil metrikleri çıkarıldı. Gruplar arası ve zaman noktaları arasındaki karşılaştırmalar için istatistiksel analizler yapıldı.Bulgular: Hipokampal volumetrik analiz, AH hastalarında Cornu Ammonis 1, (CA1),  CA2, CA4, dentat girus (DG), subikulum ve stratum radiatum-lacunosum-moleculare (SRLM) gibi alt alanlarda belirgin atrofi olduğunu ortaya koydu. TMS sonrası anlamlı bir volumetrik iyileşme gözlenmese de, sağ CA3 alt alanında progresif atrofi tespit edildi (p=0.005). Kortikal şekil analizleri, AH hastalarında hipokampal kalınlıkta (p
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UR  - https://doi.org/10.21673/anadoluklin.1595288
L1  - https://dergipark.org.tr/tr/download/article-file/4412054
ER  -