TY  - JOUR
T1  - The Evaluation of Hemodynamic and Endocrine Response and Nesfatin-1 in Patients Undergoing Inhalation and Total Intravenous Anesthesia
TT  - İnhalasyon ve Total İntravenöz Anestezi Uygulanan Hastalarda Hemodinamik, Endokrin Yanıt ve Nesfatin-1'in Değerlendirilmesi
AU  - Aksu, Ahmet
AU  - Demirel, İsmail
PY  - 2025
DA  - August
Y2  - 2025
DO  - 10.46332/aemj.1597215
JF  - Ahi Evran Medical Journal
JO  - Ahi Evran Med J
PB  - Kırşehir Ahi Evran Üniversitesi
WT  - DergiPark
SN  - 2619-9203
SP  - 142
EP  - 152
VL  - 9
IS  - 2
LA  - en
AB  - Purpose: The aim of this study was to investigate the effects of different anesthesia techniques on the surgical stress response and nesfatin-1 levels.Materials and Methods: This prospective, randomized, controlled study was conducted between March and June 2015. Ninety patients undergoing septoplasty were randomized into three groups: Desflurane + N2O (Group 1), Desflurane + Remifentanil (Group 2), and Propofol + Remifentanil (Group 3). Blood samples were collected immediately before induction, at the 30th minute in the postoperative recovery room, and at the 24th postoperative hour. Serum insulin, glucose, adrenaline, noradrenaline, cortisol, and nesfatin-1 levels were measured.Results: There were no significant differences between groups in glucose, adrenaline, noradrenaline, and nesfatin-1 levels at any time point (p > 0.05). However, insulin levels at the 24th postoperative hour were significantly higher in Group 1 compared to Group 3 (18.24 miu/ml vs. 5.52 miu/ml; p < 0.05). Cortisol levels measured at the 30th postoperative minute in Group 3 showed a significant increase compared to the other groups (10.82 μg/dl; p < 0.05).Conclusion: Different anesthesia techniques produced similar effects on hemodynamic and endocrine responses as well as nesfatin-1 levels in patients undergoing septoplasty.
KW  - surgical stress response
KW  - inhalation anesthesia
KW  - Nesfatin-1
KW  - TIVA
N2  - Amaç: Çalışmanın amacı, farklı anestezi tekniklerinin cerrahi stres yanıtı ve nesfatin-1 düzeyleri üzerindeki etkilerini araştırmaktır.Araçlar ve Yöntem: Bu çalışma, Mart-Haziran 2015 tarihleri arasında prospektif, randomize ve kontrollü olarak gerçekleştirildi. Septoplasti operasyonu geçiren 90 hasta, Desfluran + N2O (Grup 1), Desfluran + Remifentanil (Grup 2) ve Propofol + Remifentanil (Grup 3) olmak üzere üç gruba randomize edildi. Kan örnekleri indüksiyondan hemen önce, postoperatif derlenme odasında 30. dakikada ve postoperatif 24. saatte alındı. Serum insülin, glukoz, adrenalin, noradrenalin, kortizol ve nesfatin-1 düzeyleri ölçüldü.Bulgular: Gruplar arasında glukoz, adrenalin, noradrenalin ve nesfatin-1 düzeyleri açısından herhangi bir zaman noktasında anlamlı fark gözlenmedi (p > 0,05). Ancak, postoperatif 24. saatte insülin düzeyleri Grup 1’de Grup 3’e kıyasla anlamlı derecede yüksekti (sırasıyla 18,24 miu/ml ve 5,52 miu/ml; p < 0,05). Postoperatif 30. dakikada Grup 3’te ölçülen kortizol seviyeleri diğer gruplara göre anlamlı bir artış gösterdi (10,82 μg/dl; p < 0,05).Sonuç: Septoplasti geçiren hastalarda farklı anestezi teknikleri, hemodinamik ve endokrin yanıtlar ile nesfatin-1 düzeyleri üzerinde benzer etkiler göstermiştir.
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UR  - https://doi.org/10.46332/aemj.1597215
L1  - https://dergipark.org.tr/tr/download/article-file/4420868
ER  -