TY - JOUR T1 - The Role of Dynamic Susceptibility Contrast Perfusion Magnetic Resonance Imaging in the Evaluation of Active and Inactive Demyelinating Plaques in Multiple Sclerosis TT - Multipl Sklerozda Aktif ve İnaktif Demiyelinizan Plakların Değerlendirilmesinde Dinamik Duyarlılık Kontrastlı Perfüzyon Manyetik Rezonans Görüntülemenin Rolü AU - Erol, Seyit AU - Cebeci, Hakan PY - 2025 DA - June Y2 - 2025 DO - 10.54005/geneltip.1599021 JF - Genel Tıp Dergisi JO - Genel Tıp Derg PB - Selçuk Üniversitesi WT - DergiPark SN - 2602-3741 SP - 442 EP - 446 VL - 35 IS - 3 LA - en AB - BackgroundOur goal in this study was to find out if active plaques that exhibit enhancement and inactive plaques that do not differ in DSC-PWI measures in MS patients.Material and Methods:In our study, Dynamic susceptibility contrast perfusion-weighted MRI (DSC-PI) examinations of 30 patients diagnosed with Multiple Sclerosis were retrospectively analyzed. A region of interest (ROI) was manually drawn on DSC-PI between active plaques that showed enhancement on conventional MRI sequences and inactive plaques that did not show enhancement. Cerebral blood volume (CBV), cerebral blood flow (CBF), mean transit time (MTT) and time to peak (TTP) in this ROI were also recorded. These measurements were also normalized to apparently unaffected contralateral white matter hemisphere measurements. These normalized values were named rCBV, rCBF, rMTT and rTTP.Results:Both rCBV and rCBF were significantly higher in active demyelinating plaques compared to chronic demyelinating plaques (p KW - Multipl Sclerosis KW - Magnetic Resonance Imaging KW - Demyelinating disease N2 - Amaç:Bu çalışmadaki amacımız, MS hastalarında kontrastlanma gösteren aktif plakların ve göstermeyen inaktif plakların DSC-PWI ölçümlerinde farklılık olup olmadığını bulmaktı.Gereç ve Yöntemler:Çalışmamızda, Multipl Skleroz tanısı konmuş 30 hastanın Dinamik susceptibilite kontrastlı perfüzyon ağırlıklı MRG incelemeleri retrospektif olarak analiz edildi. Konvansiyonel MRG sekanslarında kontrastlanma gösteren aktif plaklar ile kontrastlanma göstermeyen inaktif plaklar arasında DSC-PI üzerinde manuel olarak bir ilgi bölgesi (ROI) çizildi. Bu ROI'deki serebral kan hacmi (CBV), serebral kan akışı (CBF), ortalama geçiş süresi (MTT) ve zirveye ulaşma süresi (TTP) de kaydedildi. Bu ölçümler ayrıca görünüşte etkilenmemiş kontralateral beyaz cevher hemisfer ölçümleri ile normalize edildi. Bu normalize edilen değerler rCBV, rCBF, rMTT ve rTTP olarak adlandırıldı.Bulgular:Hem rCBV hem de rCBF, aktif demiyelinizan plaklarda kronik demiyelinizan plaklara kıyasla anlamlı derecede yüksekti (p CR - 1. Compston A, Coles A. Multiple sclerosis. Lancet. 2008;372(9648):1502-17. CR - 2. Lublin FD, Reingold SC, Cohen JA, Cutter GR, Sørensen PS, Thompson AJ, et al. Defining the clinical course of multiple sclerosis: the 2013 revisions. Neurology. 2014;83(3):278-86. CR - 3. Soheila R, Arezoo B, Galavani H, Saber R. Comments on "Genetic characterization and phylogenetic analysis of Fasciola species based on ITS2 gene sequence, with first molecular evidence of intermediate Fasciola from water buffaloes in Aswan, Egypt". Ann Parasitol. 2021;67(2):351-2. CR - 4. Thompson AJ, Banwell BL, Barkhof F, Carroll WM, Coetzee T, Comi G, et al. 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