TY  - JOUR
T1  - ACETYLSALICYLIC  ACID RESISTANCE IN PATIENTS WITH ACUTE CORONARY SYNDROME AND ITS RELATIONSHIP BETWEEN MEAN PLATELET VOLUME
TT  - Akut Koroner Sendrom Hastalarında Asetilsalisilik Asit Direnci ve Ortalama Platelet Hacmi ile İlişkisi
AU  - Kılınç, Ali Yaşar
AU  - Uçar, Mustafa
AU  - Başarıcı, İbrahim
AU  - Avcı Demır, Fulya
AU  - Özdem, Sebahat
PY  - 2025
DA  - April
Y2  - 2025
DO  - 10.24938/kutfd.1599043
JF  - The Journal of Kırıkkale University Faculty of Medicine
JO  - Kırıkkale Uni Med J
PB  - Kırıkkale Üniversitesi
WT  - DergiPark
SN  - 2148-9645
SP  - 63
EP  - 67
VL  - 27
IS  - 1
LA  - en
AB  - Objective: Insufficient biochemical response to Acetylsalicylic Acid (ASA) is defined as 'ASA resistance'. Its prevalence is unknown. The frequency of death and cardiovascular events rises as the mean platelet volume (MPV) increases in patients with acute coronary syndrome (ACS). Patients with high MPV are more resistant to antiplatelet agents. Our study aimed to evaluate the temporal variability of ASA resistance and platelet reactivity in ACS patients and to demonstrate its relationship with MPV. Material and Methods: Our study is single-center prospective, cross-sectional study. Patients over 18 years of age who were hospitalized due to ACS and underwent percutaneous coronary intervention were included. ASA resistance and MPV measurements were taken at admission and first month. The prevalence and alteration of ASA resistance and its relationship with MPV were analyzed. Results: 115 patients were included in the study. 7 patients (6.08%) were ASA-resistant at first admission and increased to 22 (19.13%) at the 1st month follow-up (p=0.003). A significant numerical increase in ASA resistance was observed in the first month of controls (p
KW  - Acute coronary syndrome
KW  - acetylsalicylic acid
KW  - mean platelet volume
N2  - Amaç: Asetilsalisilik asite (ASA) yetersiz biyokimyasal yanıt 'ASA direnci' olarak tanımlanır. Yaygınlığı bilinmemektedir. Akut koroner sendrom (AKS) hastalarında ortalama trombosit hacmi (OTH) arttıkça mortalite ve kardiyovasküler olayların sıklığı artar. Yüksek OTH’li hastalar antiplatelet ajanlara daha dirençlidir. Çalışmamız AKS hastalarında ASA direnci ve trombosit reaktivitesinin zamansal değişkenliğini değerlendirmeyi ve OTH ile ilişkisini göstermeyi amaçlamıştır. Gereç ve Yöntemler: Çalışmamız tek merkezli prospektif, kesitsel bir çalışmadır. AKS nedeniyle hastaneye yatırılan ve perkütan koroner girişim uygulanan 18 yaş üstü hastalar çalışmaya dahil edildi. ASA direnci ve OTH ölçümleri başvuruda ve birinci ayda alındı. ASA direncinin yaygınlığı ve değişimi, OTH ile ilişkisi analiz edildi. Bulgular: Çalışmaya 115 hasta dâhil edildi. İlk başvuruda 7 hasta (%6,08) ASA dirençliydi ve 1. ay kontrolünde bu sayı 22'ye (%19,13) yükseldi (p=0,003). 1. ay kontrollerinde ASA direncindeki sayısal artış anlamlı bulundu (p
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UR  - https://doi.org/10.24938/kutfd.1599043
L1  - https://dergipark.org.tr/tr/download/article-file/4429203
ER  -