TY  - JOUR
T1  - Wnt/Beta-katenin Sinyal Yolunun Preimplantasyon, İmplantasyon, Desidualizasyon ve Plasentasyondaki Kritik Rolü
AU  - Dönmez, Hanife Güler
AU  - Beksac, M.sinan
PY  - 2025
DA  - May
Y2  - 2025
DO  - 10.63716/guffd.1617231
JF  - Gazi Üniversitesi Fen Fakültesi Dergisi
JO  - GÜFFD
PB  - Gazi Üniversitesi
WT  - DergiPark
SN  - 2757-5543
SP  - 74
EP  - 84
VL  - 6
IS  - 1
LA  - tr
AB  - Embriyo ve maternal faktörler arasındaki sıkı ilişki sağlıklı bir gebelik süreci için oldukça önemlidir. Bu noktada uterus, sağlıklı bir embriyonun gelişimine devam etmesi ya da ortadan kaldırılması için embriyoyu indüklerken, embriyo endometriyuma tutunmaya, endometriyum içine yayılmaya ve maternal immünolojik etkilere karşı hayatta kalmaya çalışmaktadır. İmplantasyon, desidual reaksiyon ve plasentasyon olayları çok sayıda sinyal yolunun birbirleri ile etkileştiği kompleks bir süreçle kontrol edilmektedir. Wnt/beta-katenin sinyal yolu da bu gelişimsel olaylarda rol oynadığı belirlenen evrimsel olarak korunmuş bir sinyal yoludur. Son bulgular, Wnt/beta-katenin sinyalindeki anormalliklerin implantasyon başarısızlığı, anormal plasenta gelişimi ve preeklampsi gibi üreme bozukluklarına katkıda bulunabileceğini göstermektedir. Bu sebeple derlememizde erişkin ve embriyonik dönemde hücre proliferasyonu, farklılaşması, adezyonu ve hücre göçü gibi çeşitli biyolojik süreçlerdeki etkisi olan Wnt/beta-katenin sinyal yolunun preimplantasyon, implantasyon, desidual reaksiyon ve plasentasyondaki rolünün literatür bilgileri eşliğinde açıklanması ve ortaya konulması amaçlanmıştır. Böylece bu derleme, Wnt/beta-Katenin sinyal yolunun üreme sürecindeki kritik rolünü daha iyi anlamamıza katkı sağlayarak, bu yoldaki bozukluklarla ilişkili komplikasyonların tanı ve tedavisinde yeni stratejilerin geliştirilmesine ışık tutmayı amaçlamaktadır.
KW  - İmplantasyon
KW  - Desidualizasyon
KW  - Plasentasyon
KW  - Wnt/beta-katenin sinyal yolu
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UR  - https://doi.org/10.63716/guffd.1617231
L1  - https://dergipark.org.tr/tr/download/article-file/4509493
ER  -