@article{article_1617920, title={Distribution and Antibiotic Susceptibility of Bacteria Isolated from Urine Culture}, journal={Genel Tıp Dergisi}, volume={35}, pages={471–475}, year={2025}, DOI={10.54005/geneltip.1617920}, author={Çiftçi, Nurullah}, keywords={Antibakteriyel direnç, Karbapenemler, Kolistin, Escherichia coli, İdrar yolu enfeksiyonu}, abstract={Background/Aims: Empiric appropriate antibiotic therapy is recommended in patients with symptoms of urinary tract infections(UTIs) as it reduces the morbidity rate. Inappropriate antibiotic use leads to a decrease in treatment effectiveness and the development of late-stage complications. The aim of this study is retrospectively evaluate the results of urine cultures from patients prediagnosed with UTIs and the antibiotic resistance rate of the bacteria. Methods: Midstream urine samples from the patients were collected in sterile screw-cap containers and transported to the laboratory following standard procedures to avoid contamination. The urine samples were cultured on appropriate media and incubated at 37°C for 24-48 hours. Bacterial identification was performed using conventional microbiological techniques. Antibiotic susceptibility testing was performed using the Kirby-Bauer disk diffusion method according to European Committee on Antimicrobial Susceptibility Testing guidelines. Results: In our study, a total of 1357 urine cultures were found to be positive for bacterial growth over one year. 1249 samples were obtained from adults, and 108 from children. The most frequently identified uropathogen in both adults and children was E. coli, with an average occurrence of 57.3%. The second most frequently isolated bacteria were Enterococcus spp. in adults and Klebsiella spp. in children. In adults, the most resistant antibiotics were found to be ampicillin(77.2%) and amoxicillin-clavulanic acid (63.3%), while the most sensitive antibiotics were carbapenems(1%). The highest resistance rate in P. aeruginosa strains were observed against ceftazidime(%38.9), while all strains were susceptible for colistin, tigecycline, and amikacin. Conclusions: The findings of this study underscore the importance of performing routine urine cultures to identify the specific pathogens causing UTIs and their susceptibility to antibiotics. Empirical treatment based on local antibiogram data is essential to ensure effective management and reduce unnecessary antibiotic use.}, number={3}, publisher={Selçuk Üniversitesi}, organization={destekleyen kurum bulunmamaktadır.}