@article{article_1621723, title={The Relationship Between Urinary System Stone Disease and Serum Fetuin-A Glycoprotein}, journal={Endoüroloji Bülteni}, volume={17}, pages={71–77}, year={2025}, DOI={10.54233/endourolbull-1621723}, author={Yavuz, Abdulmecit and Arısan, Serdar}, keywords={böbrek taşı, Üriner taş, fetuin}, abstract={Objective: This study aimed to investigate the relationship between Fetuin-A glycoprotein, a known systemic and localized calcification inhibitor, and urinary system stone disease. 
Material and Methods: A total of 63 patients with urinary stone disease and 70 healthy controls were included. Serum Fetuin-A levels were measured using enzyme-linked immunosorbent assay, and various biochemical parameters were analyzed. Statistical comparisons were performed by using Pearson correlation to determine relationships, with significance set at p<0.05. 
Results: The mean serum Fetuin-A levels were slightly higher in the stone disease group (503.5 ± 87.6 mg/dL) compared to the control group (462.7 ± 101.6 mg/dL); however, the difference was not statistically significant (p>0.05). The mean age was 42.87 ± 11.0 years in the stone group and 41.6 ± 11.7 years in the control group (p=0.497). In the stone group, 65% were male and 35% female, while in the control group, 66% were male and 34% female, with no significant difference in gender distribution (p=0.831). Body mass index (BMI) was 25.3 ± 2.57 kg/m² in the stone group and 26.9 ± 3.08 kg/m² in the control group, also showing no significant difference (p=0.067). No correlations were found between serum Fetuin-A levels and other parameters such as age, BMI, or biochemical markers. 
Conclusion: Although some previous studies have suggested a relationship between Fetuin-A levels and urinary stone disease, this study found no significant association. Further research focusing on genetic polymorphisms of Fetuin-A may clarify its role in stone formation.}, number={2}, publisher={Endoüroloji Derneği}, organization={There is no funding for the study.}