@article{article_1621868, title={Bivariate and Multivariate Calibration Approach for the Spectrophotometric Analysis of Two-Component Drugs in Real Tablets}, journal={Fabad Eczacılık Bilimler Dergisi}, volume={50}, pages={311–318}, year={2025}, DOI={10.55262/fabadeczacilik.1621868}, author={Dinç, Erdal and Üçer, Asiye and Ertekin, Zehra Ceren and Güzel, Ömer Faruk}, keywords={amlodipin, çift değişkenli kalibrasyon yöntemi, çok değişkenli kalibrasyon yöntemi, rosuvastatin, spektrofotometrik analiz, tabletlerin kantitatif tayini}, abstract={This study presents a novel and simple spectrophotometric method for simultaneously quantifying rosuvastatin (ROS) and amlodipine (AML) in tablet formulation. Due to their overlapping absorption spectra, traditional spectrophotometric techniques were inadequate for analyzing these two drugs. To address this challenge, bivariate and multivariate calibration techniques were employed for the simultaneous determination of ROS and AML. Regression equations were generated using known concentrations and corresponding absorbance values of ROS and AML across different wavelengths, specifically between 224 and 371 nm. A total of 22 different regression equations were computed to establish the bivariate calibration method. The slope values from these equations were utilized to create sensitivity matrices, and the determinant of each sensitivity matrix was calculated for various wavelength pairs. An optimal wavelength pair was selected using Kaiser’s technique, and a corresponding set of equations was constructed based on this chosen pair. The effectiveness of the proposed methods was validated through the analysis of synthetic mixtures and standard addition samples. Ultimately, the methods demonstrated a successful application for quantitatively analyzing ROS and AML in tablets.}, number={2}, publisher={FABAD Ankara Eczacılık Bilimleri Derneği}