TY  - JOUR
T1  - Biberiye uçucu yağ örneklerinin kalite kontrol açısından değerlendirilmesi
TT  - Evaluation of rosemary essential oil samples in terms of quality control
AU  - Fafal, Tuğçe
AU  - Yıldırım, Fatma
PY  - 2025
DA  - May
Y2  - 2025
DO  - 10.31020/mutftd.1625732
JF  - Mersin Üniversitesi Tıp Fakültesi Lokman Hekim Tıp Tarihi ve Folklorik Tıp Dergisi
PB  - Mersin Üniversitesi
WT  - DergiPark
SN  - 1309-8004
SP  - 631
EP  - 639
VL  - 15
IS  - 2
LA  - tr
AB  - Amaç: Bu çalışmada, piyasadan temin edilen dört farklı ticari biberiye (Rosmarinus officinalis L.) uçucu yağı ile laboratuvar koşullarında distilasyon yoluyla elde edilen uçucu yağ örneği Türk Farmakope’sinde Aetheroleum Rosmarini monografında yer alan kalite kontrol parametrelerine göre analiz edilmiştir.Yöntem: Çalışma materyali olarak, ticari olarak temin edilen dört biberiye uçucu yağı ve distilasyonla elde ettiğimiz uçucu yağ örneği kullanılmıştır. Tüm örnekler, Türk Farmakope’sinde yer alan Aetheroleum Rosmarini monografında yer alan kalite kontrol analizlerine tabi tutulmuştur. Analitik ölçümler standart çalışma protokollerine uygun şekilde gerçekleştirilmiştir.Bulgular: Makroskobik değerlendirme, bağıl yoğunluk, kırılma indisi ve alkolde çözünürlük analizleri, örnekler arasında genel olarak benzerlik göstermiştir ve bu parametrelerde ciddi bir sapma gözlenmemiştir. Gaz kromatografisi analizinde ise ticari örneklerden yalnızca ikisi, farmakope tarafından öngörülen aralıkta ökaliptol (1,8-sineol) içeriğine sahipken (%38-55), diğer iki örnekte bu majör bileşenin miktarı farmakope limitlerinin altında kalmıştır. Leke testinde ise ticari uçucu yağların üçünde sabit yağ varlığı saptanmıştır.Sonuç: Gaz kromatografisi ve leke testi sonuçları, bazı uçucu yağ örneklerinin farmakope kriterlerine uygun olmadığını ortaya koymuştur. Toplanan drogtan distilasyon ile elde edilen uçucu yağ örneği Türk Farmakopesi standartlarıyla uyum göstermiştir. Bu bulgular, piyasada bulunan uçucu yağların kalite kontrolünün yapılmasının, farmakope kriterlerine uygunluklarının denetlenmesinin ve etiket ile bu bilgilerin ürün üzerinde yer almasının tüketici güvenliği ve terapötik etkinlik açısından önem taşıdığını göstermektedir.
KW  - uçucu yağ
KW  - Aetheroleum Rosmarini
KW  - Rosmarinus officinalis
N2  - Objective: In this study, four different commercial rosemary (Rosmarinus officinalis L.) essential oil samples obtained from the market and the essential oil samples obtained by distillation in laboratory conditions were analyzed according to the quality control parameters included in the Aetheroleum Rosmarini monograph in the Turkish Pharmacopoeia.Method: Four commercially available rosemary essential oils and essential oil samples obtained by distillation were used as study materials. All samples were subjected to quality control analyses in the Aetheroleum Rosmarini monograph in the Turkish Pharmacopoeia. Analytical measurements were performed in accordance with standard working protocols.Results: Macroscopic evaluation, relative density, refractive index and alcohol solubility analyses showed general similarity among the samples and no serious deviations were observed in these parameters. In gas chromatography analysis, only two of the commercial samples had eucalyptol (1,8-cineole) content within the range prescribed by the pharmacopoeia (38-55%), while the amount of this major component in the other two samples remained below the pharmacopoeia limits. In the spot test, the presence of fixed oil was detected in three of the commercial essential oils.Conclusion: Gas chromatography and spot test results revealed that some essential oil samples did not comply with the pharmacopoeia criteria. The essential oil sample obtained by distillation from the collected drug complied with the Turkish Pharmacopoeia standards. These findings show that quality control of essential oils available on the market, checking their compliance with pharmacopoeial criteria and including this information on the product label are important for consumer safety and therapeutic efficacy.
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UR  - https://doi.org/10.31020/mutftd.1625732
L1  - https://dergipark.org.tr/tr/download/article-file/4546811
ER  -