@article{article_1626195, title={Atypical Serology Profiles in Hepatitis B Cases: A Retrospective Analysis}, journal={Acta Medica Alanya}, volume={9}, pages={124–129}, year={2025}, author={Bozdemir, Tuğba and Özkarataş, Emre and Timur, Demet and Demirpek, Uğur and Çalışkan Gürsev, Nuray}, keywords={Hepatit B, Seroloji, Tanı}, abstract={Aim: Understanding antigen-antibody profiles in hepatitis B virus (HBV) infection is essential for accurate diagnosis and clinical assessment. Although standard serological patterns are well defined, variations in viral protein expression and host immune responses can result in the loss of expected antibodies and the emergence of atypical serological profiles. Such deviations may complicate the interpretation of diagnostic and follow-up testing. This study retrospectively analyzed cases presenting with atypical HBV serological findings. Methods: Patient data from HBV serology tests conducted at the Microbiology Laboratory of Bursa City Hospital were reviewed from hospital records. Additional tests, including HBV polymerase chain reaction (PCR), hepatitis C virus (HCV) tests (anti-HCV, HCV PCR), and human immunodeficiency virus (HIV) tests (anti-HIV, HIV confirmation), were evaluated in patients with isolated anti-HBc positivity. Patients were categorized on the basis of their HBeAg and anti-HBe status, and the means and standard deviations of the HBV viral load values were calculated. Results: Atypical HBV serological profiles were identified in 1404 patients (0.49%). The most common atypical profile was isolated anti-HBc positivity, which was observed in 5.27% (n=1079) of the patients. Among 119 the patients tested with HBV PCR, 12 had detectable HBV DNA. Among the 23 patients whose HCV PCR results were tested, 13 had detectable HCV RNA. Three of the 995 patients tested for anti-HIV were reactive, with two confirmed as HIV-1 positive by confirmatory testing. Conclusion: This study investigated the prevalence and characteristics of atypical HBV serological profiles among patients at Bursa City Hospital. Such profiles may arise due to false reactivity or reflect different stages of infection. Comprehensive evaluation and appropriate clinical management are essential for patients exhibiting these atypical patterns.}, number={2}, publisher={Alanya Alaaddin Keykubat Üniversitesi}