TY  - JOUR
T1  - Atypical Serology Profiles in Hepatitis B Cases: A Retrospective Analysis
TT  - Hepatit B Olgularında Atipik Seroloji Profilleri: Retrospektif Bir Analiz
AU  - Bozdemir, Tuğba
AU  - Özkarataş, Emre
AU  - Timur, Demet
AU  - Demirpek, Uğur
AU  - Çalışkan Gürsev, Nuray
PY  - 2025
DA  - August
Y2  - 2025
JF  - Acta Medica Alanya
JO  - Acta Med. Alanya
PB  - Alanya Alaaddin Keykubat Üniversitesi
WT  - DergiPark
SN  - 2587-0319
SP  - 124
EP  - 129
VL  - 9
IS  - 2
LA  - en
AB  - Aim: Understanding antigen-antibody profiles in hepatitis B virus (HBV) infection is essential for accurate diagnosis and clinical assessment. Although standard serological patterns are well defined, variations in viral protein expression and host immune responses can result in the loss of expected antibodies and the emergence of atypical serological profiles. Such deviations may complicate the interpretation of diagnostic and follow-up testing. This study retrospectively analyzed cases presenting with atypical HBV serological findings.Methods: Patient data from HBV serology tests conducted at the Microbiology Laboratory of Bursa City Hospital were reviewed from hospital records. Additional tests, including HBV polymerase chain reaction (PCR), hepatitis C virus (HCV) tests (anti-HCV, HCV PCR), and human immunodeficiency virus (HIV) tests (anti-HIV, HIV confirmation), were evaluated in patients with isolated anti-HBc positivity. Patients were categorized on the basis of their HBeAg and anti-HBe status, and the means and standard deviations of the HBV viral load values were calculated.Results: Atypical HBV serological profiles were identified in 1404 patients (0.49%). The most common atypical profile was isolated anti-HBc positivity, which was observed in 5.27% (n=1079) of the patients. Among 119 the patients tested with HBV PCR, 12 had detectable HBV DNA. Among the 23 patients whose HCV PCR results were tested, 13 had detectable HCV RNA. Three of the 995 patients tested for anti-HIV were reactive, with two confirmed as HIV-1 positive by confirmatory testing.Conclusion: This study investigated the prevalence and characteristics of atypical HBV serological profiles among patients at Bursa City Hospital. Such profiles may arise due to false reactivity or reflect different stages of infection. Comprehensive evaluation and appropriate clinical management are essential for patients exhibiting these atypical patterns.
KW  - Hepatitis B
KW  - Serology
KW  - Diagnosis
N2  - Amaç: Hepatit B virüsü (HBV) enfeksiyonu sırasında konakçı tarafından üretilen antijen-antikor profillerinin incelenmesi, enfeksiyon tanısı ve klinik seyrin değerlendirilmesinde önemli yere sahiptir. Serolojik profiller büyük ölçüde tanımlanmış olsa da, viral protein ekspresyonundaki varyasyonlar ve antikor immünojenisitesine bağlı farklılıklar, antikor yanıtında beklenmeyen kayıplara ve alışılmadık serolojik sonuçlara yol açabilmektedir. Bu atipik serolojik profiller tanı ve izlem sırasında enfeksiyonun yorumlanmasında zorluklara yol açabilir. Bu çalışmada, HBV enfeksiyonu yönünden incelenen hastalarda görülen atipik HBV seroloji sonuçlarının retrospektif olarak değerlendirilmesi amaçlanmıştır.Yöntem: Bursa Şehir Hastanesi Mikrobiyoloji Laboratuvarı'nda çeşitli nedenlerle HBV seroloji testleri araştırılan hastaların sonuçları hastane otomasyon sistemi kayıtlarından retrospektif olarak incelendi. Ayrıca izole anti-HBc pozitifliği olan hastalarda HBV Polimeraz Zincir Reaksiyonu (PCR), Hepatit C virüsü (HCV) testleri (anti-HCV, HCV PCR) ve insan immün yetmezlik virüsü (HIV) testleri (anti-HIV, HIV doğrulama) değerlendirildi. Hastalar HBeAg ve anti-HBe durumlarına göre analiz edildi ve HBV viral yük değerlerinin ortalaması ve standart sapması hesaplandı.Bulgular: Atipik HBV serolojik profili 1404 (%0.49) hastada tespit edilmiştir. En sık saptanan atipik profil izole anti-HBc pozitifliği (n: 1079, %5.27) olmuştur. Bu gruptaki 119 hastada HBV PCR yapılmış, 12 hastada HBV DNA saptanmıştır. HCV PCR çalışılan 23 hastadan 13’ünde HCV RNA pozitifliği tespit edilmiştir. Anti-HIV testi yapılan 995 hastanın üçü reaktif bulunmuş, bunlardan ikisinin HIV-1 doğrulama testi pozitif sonuçlanmıştır.Sonuç: Bu çalışma ile Bursa Şehir Hastanesi’ne başvuran hastalarda HBV atipik serolojik profillerinin varlığı ve oranları tespit edilmiştir. Atipik serolojik profiller, yalancı reaktiviteden akut-kronik enfeksiyona kadar farklı durumlardan kaynaklı olabilir. İleri tetkik ve tedavi bu profil saptanan hastalarda önemlidir.
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UR  - https://dergipark.org.tr/tr/pub/medalanya/issue//1626195
L1  - https://dergipark.org.tr/tr/download/article-file/4548857
ER  -