@article{article_1628952, title={Investigation of Plasma Spexin, Visfatin and Leptin Levels in Patients with Diabetic Neuropathy}, journal={Medical Research Reports}, volume={8}, pages={78–91}, year={2025}, DOI={10.55517/mrr.1628952}, author={Özkan İbiş, Adeviye and Özturan Özer, Huriye Eda and Sarıçam, Gülhan and Sarıçam, Orkun and Ergün, Ahmet}, keywords={Diyabetik nöropati, Speksin, Visfatin, Leptin, Diyabetes Mellitus}, abstract={Aim: Diabetic neuropathy (DN) is one of the most common chronic complications of diabetes mellitus (DM). The aim of this study was to investigate plasma spexin, visfatin and leptin levels of patients with Type 2 DM who developed DN as a complication and patients who did not develop DN and to determine whether any significant differences existed between the groups. Method: The study included 93 patients diagnosed with type 2 DM. Electromyography (EMG) was performed as an electrophysiologic nerve conduction study. According to EMG results, patients were divided into two groups: those with DN (n=55) and those without (n=38). Two tubes of venous blood samples (5 ml each) were collected from each patient. HbA1c levels of patients were checked in the first blood sample. According to HbA1c levels, the groups were divided into two subgroups as HbA1c between 6.5-8.4 and ≥8.5, and a total of four study groups were formed. The second blood sample was separated into plasma, spexin, visfatin and leptin levels were determined by ELISA method. The results were compared between the groups. Results: Of the participants with DN, 31 were female and 24 were male. Of those without DN, 29 were female and 9 were male. DN patients had significantly higher glucose and HbA1c values than those without (p<0.05). When lipid profiles were compared, although total cholesterol and triglyceride levels were high in both groups, the difference was not statistically significant (p>0.05). There was no significant difference between groups in terms of High Density Lipoprotein (HDL) levels. Low Density Lipoprotein (LDL) levels were higher in the non-DN group, but not significantly (p>0.05). Body mass index (BMI), glucose, triglycerides, total cholesterol, HDL, LDL, spexin, visfatin and leptin values of patients with and without DN with HbA1c levels between 6.5-8.4 did not show statistically significant difference according to the diagnosis of neuropathy (p>0.05). Among patients with HbA1c level ≥8.5, there was no statistically significant difference between BMI, glucose, triglyceride, HDL, spexin, visfatin and leptin levels of patients with and without DN (p>0.05), whereas there was a statistically significant difference between total cholesterol and LDL levels of the same group (p<0.05). LDL levels were higher in patients with DN. When the correlation between spexin, visfatin, and leptin levels of patients with and without DN was examined, a strong and statistically significant positive correlation was found between them (p<0.01).Conclusion: Plasma levels of spexin, visfatin and leptin did not differ significantly between the groups of patients with and without DN. However, a significant positive correlation was found between plasma spexin, visfatin and leptin levels of the patients. This result suggests that plasma levels of spexin, visfatin and leptin act together and may be clinically important.}, number={2}, publisher={M. Tayyib KADAK}, organization={Bu çalışma Başkent Üniversitesi Tıp ve Sağlık Bilimleri Araştırma Kurulu ve Etik Kurulu tarafından onaylanmış (Proje no: KA22/202) ve Başkent Üniversitesi Araştırma Fonunca desteklenmiştir.}