TY  - JOUR
T1  - HER ANTİ NÖTROFİL SİTOPLAZMİK ANTİKOR (ANCA) POZİTİFLİĞİ ROMATOLOJİK HASTALIKLA İLİŞKİLİ MİDİR?
TT  - Is Every Anti-Neutrophil Cytoplasmic Antibody (ANCA) Positivity Associated With Rheumatologic Disease?
AU  - Batıbay, Sevilay
AU  - Bozkurt, Tuğçe
AU  - Dinçses Nas, Elif
PY  - 2025
DA  - April
Y2  - 2025
DO  - 10.24938/kutfd.1632585
JF  - The Journal of Kırıkkale University Faculty of Medicine
JO  - Kırıkkale Uni Med J
PB  - Kırıkkale Üniversitesi
WT  - DergiPark
SN  - 2148-9645
SP  - 95
EP  - 99
VL  - 27
IS  - 1
LA  - tr
AB  - Amaç: Anti-nötrofil sitoplazmik antikor (ANCA) saptanan hastalarda romatolojik hastalık saptanma oranını ve ANCA ilişkili vaskülit (AİV) dışında ANCA pozitifliğine yol açan diğer durumları belirlemeyi amaçladık. Gereç ve Yöntemler: İstanbul Medeniyet Üniversitesi, Göztepe Prof. Dr. Süleyman Yalçın Şehir Hastanesi Romatoloji polikliniğinde Ocak 2023-Kasım 2024 tarihleri arasında ANCA pozitifliği nedeniyle değerlendirilen 18-90 yaş aralığındaki 76 erişkin geriye dönük değerlendirildi. Hastaların demografik verileri, ANCA titresi ve paterni, diğer laboratuvar parametreleri, romatolojik olarak değerlendirilmesi neticesindeki nihai tanıları kaydedildi. Romatolojik hastalık tanısı alan hastalar grup 1, almayanlar ise grup 2 olarak sınıflandırıldı. Bulgular: 76 hasta retrospektif olarak değerlendirildi. Hastaların 51’i (%67) kadın, 25’i (%33) erkek idi. Hastaların ortanca yaşı 60,5’ti (min-max:24-84). 40 (%52,6) hastada p- ANCA, 10 (%13,2) hastada c-ANCA saptanırken, 21’inde (%22,6) MPO ANCA, 33’ünde (%43,6) PR3 ANCA pozitifti. 39’u (%51,3) romatolojik hastalık tanısı aldı, bunların 23’ü (%30,3) AİV idi. İki enfektif endokardit, birer hastada akciğer kanseri, tüberküloz, ülseratif kolit ve kronik ürtiker saptandı. Grup 1’de PR3 ANCA titresi, sedimentasyon ve CRP değerleri Grup 2’ye göre anlamlı olarak daha yüksekti (sırasıyla p
KW  - Antinötrofil sitoplazmik antikor
KW  - c-ANCA
KW  - p-ANCA
KW  - anti-nötrofil sitoplazmik antikor-ilişkili vaskülit
N2  - Objective: We aimed to determine the rate of rheumatological disease detection in patients with anti-neutrophil cytoplasmic antibody (ANCA) and other conditions that lead to ANCA positivity other than ANCA-associated vasculitis (AIV). Material and Methods: A retrospective evaluation was made of 76 adults aged 18-90 years who were evaluated for ANCA positivity at the Rheumatology Clinic of İstanbul Medeniyet University, Göztepe Prof. Dr. Süleyman Yalçın City Hospital between January 2023 and November 2024. Demographic parameters, ANCA titer and pattern, other laboratory values, and final diagnoses as a result of rheumatological evaluation of the patients were recorded. Patients diagnosed with rheumatological diseases were classified as group 1, and patients without were classified as group 2. Results: Seventy-six patients were evaluated retrospectively. Fifty-one (67%) patients were female and 25 (33%) were male. The median age of the patients was 60.5 (min-max:24-84). p- ANCA was detected in 40 patients (52.6%), c-ANCA was detected in 10 (13.2%), MPO ANCA was positive in 21 (22.6%), and PR3 ANCA was positive in 33 (43.6%). 39 (51.3%) were diagnosed with rheumatologic disease, 23 of which were AIV. Infective endocarditis was detected in two patients, and lung cancer, tuberculosis, ulcerative colitis, and chronic urticaria were detected in one patient each. PR3 ANCA titer, sedimentation and CRP values were significantly higher in Group 1 than in Group 2 (p
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UR  - https://doi.org/10.24938/kutfd.1632585
L1  - https://dergipark.org.tr/tr/download/article-file/4577008
ER  -