@article{article_1633661, title={Evaluation of Serum Neopterin and Procalcitonin Levels in Dogs with Ascariasis}, journal={Erciyes Üniversitesi Veteriner Fakültesi Dergisi}, volume={22}, pages={119–125}, year={2025}, DOI={10.32707/ercivet.1633661}, author={Batı, Yusuf Umut and Merhan, Oğuz and Akyüz, Enes and Sezer, Mert and Erkılıç, Ekin Emre and Kırmızıgül, Ali Haydar}, keywords={Askarid, köpek, neopterin, prokalsitonin}, abstract={Ascariasis is a commonly encountered parasitic infection in dogs that can lead to gastrointestinal damage and systemic inflammatory responses. However, studies evaluating the role of inflammatory biomarkers in the diagno-sis of ascariasis remain limited. The aim of this study was to evaluate the association between ascariasis and the lev-els of inflammatory biomarkers, specifically serum neopterin and procalcitonin, in dogs. The study included 15 puppies aged between 1 and 6 months, diagnosed with ascariasis, and 10 clinically healthy control dogs. All animals were of different breeds and included both males and females. A single blood sample was collected from both infected and healthy animals. The samples were centrifuged at 3000 rpm for 10 minutes to separate the serum. The analysis re-vealed that serum neopterin (5.06±0.50 nmol/L) and procalcitonin (68.47±2.86 pg/mL) levels in the infected dogs were significantly higher (P <0.05) than those observed in healthy controls (neopterin: 3.67±0.26 nmol/L; procalcitonin: 57.42±3.91 pg/mL). The study concludes that gastrointestinal damage caused by ascariasis is associated with in-creased serum levels of neopterin and procalcitonin. These biomarkers may have clinical value in supporting the differ-ential diagnosis of parasitic infections associated with inflammatory responses in dogs, and they may contribute to the early detection and monitoring of disease severity. Further studies with larger sample sizes and a broader panel of inflammatory markers are warranted to validate these findings and to better elucidate the role of neopterin and procalcitonin in the immunopathogenesis of canine ascariasis.}, number={2}, publisher={Erciyes Üniversitesi}, organization={Destekleyen herhangi bir kurum yoktur.}