TY  - JOUR
T1  - Evaluation of the Effectiveness of Tarantula Cubensis Extract in Cats Diagnosed with Stomatitis
TT  - Stomatitis Tanısı Konan Kedilerde Tarantula Cubensis Ekstraktının Etkinliğinin Değerlendirilmesi
AU  - Tanrısever, Murat
AU  - Türkarslan, Faruk
AU  - Ünsaldı, Emine
PY  - 2025
DA  - June
Y2  - 2025
DO  - 10.47027/duvetfd.1633969
JF  - Dicle Üniversitesi Veteriner Fakültesi Dergisi
JO  - Dicle Üniv Vet Fak Derg
PB  - Dicle Üniversitesi
WT  - DergiPark
SN  - 1307-9972
SP  - 13
EP  - 18
VL  - 18
IS  - 1
LA  - en
AB  - Stomatitis in cats is an immune response to antigenic stimuli, exacerbated by viral infections. The etiopathogenesis of this disease, which manifests itself with sores in the mouth, has not been fully clarified. Today, in addition to medical treatment, partial or complete molar extractions are also performed. In this study, the results of using tarantula cubensis extract in addition to antibiotic treatment in the treatment of cats diagnosed with stomatitis at the Fırat University Animal Hospital Small Animal Surgery Clinic in Elazığ and the Hekimköy Veterinary Clinic in Adana were investigated. The cats were evaluated in two groups. The cats in the first group (ANT) (n=10) received amoxicillin clavulanic acid treatment, and the cats in the second group (EXT) (n=10) received tarantula cubensis extract injections in addition to the same antibiotic treatment. The response to the treatments was evaluated by 3 different surgeons, one week apart, by macroscopic inspection and scored between 1 and 4. The obtained data were statistically evaluated with the Mann Whitney U test and Wilcoxon tests. In this study, a statistically significant improvement was observed in cats treated with tarantula cubensis extract in addition to antibiotic treatment compared to cats treated with antibiotics alone.
KW  - Cat
KW  - stomatitis
KW  - tarantula cubensis extract
N2  - Kedilerde stomatitis antijenik uyarılara karşı, viral enfeksiyonlar ile şiddetlenen, bağışıklık sisteminin verdiği bir tepkidir. Ağız içerisinde çıkan yaralarla kendini gösteren bu hastalığın etiyopatogenezisi tam olarak netlik kazanmamıştır. Günümüzde medikal tedavi yanı sıra kısmi veya tüm azı dişlerin çekimi de yapılmaktadır. Bu çalışmada, Elazığ’da Fırat Üniversitesi Hayvan Hastanesi Küçük Hayvan Cerrahi Kliniği’ne ve Adana’da Hekimköy Veteriner Kliniği’nde stomatitis tanısı konulan kedilerin tedavisinde antibiyotik tedavisine ek olarak tarantula cubensis ekstraktının kullanımının sonuçları araştırıldı. Kediler iki grup halinde değerlendirmeye alındı. Birinci gruptaki (ANT) kedilere (n=10) amoksisilin klavulanik asit tedavi yapıldı, ikinci gruptaki (EXT) kedilere (n=10) ise aynı antibiyotik tedavisine ek olarak tarantula cubensis ekstraktı enjeksiyonları yapıldı. Tedavilere verilen yanıt 3 ayrı cerrah tarafından, birer hafta arayla makroskobik yönden inspeksiyon ile değerlendirilerek ve 1 ile 4 arasında skorlandı. Elde edilen veriler istatistiksel açıdan Mann Whitney U testi ve Wilcoxon testleri ile değerlendirildi. Yapılan bu araştırmada antibiyotik tedavisine ek olarak tarantula cubensis ekstraktı ile tedavi edilen kedilerde, tek başına antibiyotik tedavisi yapılan kedilere kıyasla istatistiksel olarak anlamlı bir iyileşme olduğu görüldü.
CR  - Johnessee JS, Hurvitz AI (1983). Feline plasma cell gingivitis–pharyngitis, JAAHA, 19:179–181.
CR  - White SD, Rosychuk RA, Janik TA, Denerolle P, Schultheiss P (1992). Plasma cell stomatitis-pharyngitis in cats: 40 cases (1973-1991). JAAHA, 200(9):1377-1380.
CR  - Thompson RR, Wilcox GE, Clark WT, Jansen KL (1984). Association of calicivirus infection with chronic gingivitis and pharyngitis in cats. JSAP. 25:207-210.
CR  - Lommer MJ, Verstraete FJ (2003). Concurrent oral shedding of feline calicivirus and feline herpesvirus 1 in cats with chronic gingivostomatitis. Oral Microbiol Immun., 18(2):131-134.
CR  - Reindel JF, Trapp AL, Armstrong PJ, Stickle RL (1987). Recurrent plasmacytic stomatitis-pharyngitis in a cat with esophagitis, fibrosing gastritis, and gastric nematodiasis. JAVMA, 190(1):65-67.
CR  - Gaskell RM, Gruffydd Jones T (1977). Intractable feline stomatitis. Veterinary Annual., 17:195-199.
CR  - Hennet PR, Camy GA, McGahie DM, Albouy MV (2011). Comparative efficacy of a recombinant feline interferon omega in refractory cases of calicivirus-positive cats with caudal stomatitis: a randomised, multi-centre, controlled, double-blind study in 39 cats. J Feline Med Surg., 13(8):577–587.
CR  - Southerden P (2010). Review of feline oral disease. In Practice, 32(2):51.
CR  - Hennet PR (1997). Chronic gingivo-stomatitis in cats: long-term follow-up of 30 cases treated by dental extractions. J. Vet. Dent., 14:15-21.
CR  - Druet I, Hennet P (2017). Relationship between Feline calicivirus Load, Oral Lesions, and Outcome in Feline Chronic Gingivostomatitis (Caudal Stomatitis): Retrospective Study in 104 Cats. Front. Vet. Sci., 4:209.
CR  - Jennings MW, Lewis JR, Soltero-Rivera MM, Brown DC, Reiter AM (2015). Effect of tooth extraction on stomatitis in cats: 95 cases (2000-2013). JAAHA., 246(6):654-660.
CR  - DeForge DH (2004). Images in veterinary dental practice. Ulcerative lymphoplasmacytic stomatitis syndrome. J Am Vet Med Assoc., 224:207-208.
CR  - Harvey CE (1991). Oral inflammatory diseases in cats. JAVMA., 27:585-591.
CR  - Winer JN, Arzi B, Verstraete FJ (2016). Therapeutic Management of Feline Chronic Gingivostomatitis: A Systematic Review of the Literature. Front. Vet. Sci., 3:54.
CR  - Lyon KF (2005). Gingivostomatitis. Vet Clin North Am Small Anim Pract., 35(4):891–911.
CR  - Wiggs RB (2007). Lymphocytic Plasmacytic Stomatitis. In: The Feline Patient. Norsworthy GD. (Ed.) Third ed. Iowa, Blackwell.
CR  - Diehl K, Rosychuk RA (1993). Feline gingivitis-stomatitis-pharyngitis. Vet Clin North Am Small Anim Pract., 23(1):139-153.
CR  - Mihaljevic SY (2003). First clinical experiences with omega-interferon in the treatment of chronic gingivitis-stomatitis-oropharyngitis of cats. Praktische Tierarzt, 84:350-361.
CR  - Taşkaya Ş, Demirkan İ, Çevik Demirkan A, Korkmaz M (2013). Kedi Gingivitis Sağaltımında Amoksisilin – Klavulanik Asit ve Sulfadimetilprimidin – Trimetoprim Ajanlarının Klinik Etkilerinin Karşılaştırılması. Atatürk Üniversitesi Vet. Bil. Derg., 8(3):216-223.
CR  - Vercelli A, Raviri G, Cornegliani L (2006). The use of oral cyclosporin to treat feline dermatoses: a retrospective analysis of 23 cases. Vet Dermatol,17(3):201-216.
CR  - Lommer MJ (2013). Efficacy of cyclosporine for chronic, refractory stomatitis in cats: A randomized, placebo-controlled, double-blinded clinical study. J. Vet. Dent., 30(1):8-17.
CR  - Arzi B, Clark KC, Sundaram A, et al. (2017). Therapeutic efficacy of fresh, allogeneic mesenchymal stem cells for severe refractory feline chronic gingivostomatitis. Stem Cells Transl Med., 6(8):1710-1722.
CR  - Albay MK, Şahinduran Ş, Kale M, Karakurum MÇ, Sezer K (2009). Influence of Tarantula cubensis Extract on the Treatment of the Oral Lesions in Cattle with Bluetongue Disease. Kafkas Univ. Vet. Fak. Derg., 16 (4):593-596.
UR  - https://doi.org/10.47027/duvetfd.1633969
L1  - https://dergipark.org.tr/tr/download/article-file/4583048
ER  -