TY  - JOUR
T1  - Optimization of Emulsification Parameters for Chasteberry Essential Oil Aqueous Nanoemulsions
TT  - Hayıtotu Esansiyel Yağı Sulu Nanoemülsiyonları için Emülsifikasyon Parametrelerinin Optimizasyonu
AU  - Ozen, İlhan
AU  - Demiryürek, Oğuz
PY  - 2025
DA  - April
Y2  - 2025
JF  - Erciyes Üniversitesi Fen Bilimleri Enstitüsü Fen Bilimleri Dergisi
PB  - Erciyes Üniversitesi
WT  - DergiPark
SN  - 1012-2354
SP  - 254
EP  - 266
VL  - 41
IS  - 1
LA  - en
AB  - Chasteberry essential oil (CEO) is known as an efficient compound for women’s health. Yet, to make it more efficient, it should be preserved until use. One option for this purpose is to prepare its nanoemulsions. Here, feasibility of CEO nanoemulsion formulation development was reported without the need of co-surfactants and co-solvents employing a simple ultrasonication process, which was complemented by statistical evaluation. To that end, CEO NEs were prepared using an ultrasonic homogenizer using only water as the solvent and Tween80 (T80) as the emulsifier. Variations in the emulsification parameters such as emulsifier concentration (CEO/T80 ratio: 1/0, 1/1, 1/2, and 1/4) and ultrasonication time (0, 1, 5, 10, and 20 min) were tested. Turbidity measurements and morphology analyses were performed in addition to dynamic light scattering measurements. On the basis of statistical evaluation of droplet size and Zeta potential values, the best emulsification process parameters were revealed. The minimum droplet size (estimate: 37 nm) was achieved accompanying by a high Zeta potential value of -36 mV when employed an ultrasonication time of 10.55 min by using T1 (CEO/T80: 1/1). Morphology analyses delivered complementary results.
KW  - Chasteberry oil
KW  - Tween80
KW  - Ultrasonication
KW  - nanoemulsion
N2  - Öz: Hayıtotu esansiyel yağı (HEY) kadın sağlığı için etkili bir bileşen olarak bilinmektedir. Ancak HEY’in daha etkin olması için kullanımına kadar korunması gerekmektedir. Bu amaç için bir seçenek, HEY’in nanoemülsiyonlarını (NE) hazırlamaktır. Burada HEY NE formülasyonlarının basit bir ultrasonikasyonla yüzeyaktif madde ve yardımcı çözgen gereksinimi olmadan yapılabilirliği ve istatistiksel değerlendirmesi raporlanmıştır Bu amaçla HEY NE’ler çözgen olarak sadece su ve emülgatör olarak Tween80 (T80) kullanılarak ultrasonik homojenleştirici ile hazırlanmıştır. Emülgatör konsantrasyonu (HEY/T80 oranı: 1/0, 1/1, 1/2 ve 1/4) ve ultrasonikasyon süresi (0, 1, 5, 10, ve 20 dk.) gibi emülsifikasyon parametrelerindeki varyasyonlar test edilmiştir. Dinamik ışık saçılımı ölçümlerine ilaveten bulanıklık ölçümleri ve morfoloji analizleri gerçekleştirilmiştir. Damlacık boyutu ve Zeta potansiyeli verilerinin istatistiksel değerlendirmesine göre en iyi emülsifikasyon parametreleri ortaya çıkarılmıştır. T1 (HEY/T80: 1/1) kullanılarak 10.55 dk’lık ultrasonikasyon süresinde -36 mV’luk yüksek bir Zeta potansiyeli eşliğinde en küçük damlacık boyutunun (tahmin değeri: 37 nm) elde edilebileceği gösterilmiştir. Morfoloji analizleri tamamlayıcı sonuçlar vermiştir.
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UR  - http://dergipark.org.tr/tr/pub/erciyesfen/issue//1634458
L1  - http://dergipark.org.tr/tr/download/article-file/4585196
ER  -