TY - JOUR T1 - The Association between GHRL and LEP Gene Polymorphisms and ADHD: Evidence from a Pediatric Cohort TT - GHRL ve LEP Gen Polimorfizmleri ile DEHB Arasındaki İlişki: Pediatrik Kohorttan Kanıtlar AU - Cenik, Murat AU - Kilic, Ali Atabek AU - Şahin, Nilfer AU - Demirtas Bilgic, Aysegul AU - Özdemir, Çilem AU - Edgünlü, Tuba PY - 2025 DA - August Y2 - 2025 DO - 10.29058/mjwbs.1641420 JF - Medical Journal of Western Black Sea JO - Med J West Black Sea PB - Zonguldak Bülent Ecevit Üniversitesi WT - DergiPark SN - 2822-4302 SP - 214 EP - 221 VL - 9 IS - 2 LA - en AB - Aim: Dopaminergic neurons and dopamine transporters show variations in Attention Deficit Hyperactivity Disorder (ADHD). Furthermore,Ghrelin and leptin, hormones recognized for their neurotrophic effects, are significant in central nervous system regulation, influencingneuronal survival and development.Material and Methods: This study aimed to examine the potential relationship between Attention Deficit Hyperactivity Disorder (ADHD) andpolymorphisms in the GHRL (rs34911341) and LEP (rs7799039) genes. The research sample consisted of 29 children diagnosed with ADHDand 24 age-matched healthy controls. Genotypic analysis was conducted using the polymerase chain reaction-restriction fragment lengthpolymorphism (PCR-RFLP) technique.Results: A significant difference in genotype distribution for the GHRL gene rs34911341 polymorphism was observed between the ADHDgroup and healthy controls (p = 0.036), whereas allele frequencies did not show a statistically significant difference (p = 0.207). In contrast,analysis of the LEP gene rs7799039 polymorphism revealed no significant differences in either genotype (p = 0.579) or allele frequencies (p= 0.558) between the two groups.Conclusion: These findings suggest a potential role for the GHRL rs34911341 polymorphism in the development or presentation of ADHD.Further research is required to elucidate the mechanisms underlying this association. KW - ADHD KW - Development KW - GHRL KW - LEP KW - polymorphism N2 - Amaç: Dopaminerjik nöronlar ve dopamin taşıyıcıları Dikkat Eksikliği Hiperaktivite Bozukluğu'nda (DEHB) farklılıklar gösterir. Ayrıca,nörotrofik etkileriyle tanınan hormonlar olan Ghrelin ve leptin, nöronal sağ kalımı ve gelişimi etkileyerek merkezi sinir sistemi düzenlemesindeönemlidir.Gereç ve Yöntemler: Bu çalışmanın amacı, DEHB ile GHRL (rs34911341) ve LEP (rs7799039) polimorfizmleri arasındaki ilişkiyi araştırmaktır.Çalışmaya DEHB tanısı almış 29 çocuk ve 24 sağlıklı çocuk dahil edildi. Genotipleme, PCR-RFLP (polimeraz zincir reaksiyonu-restriksiyonparça uzunluğu polimorfizmi) yöntemi aracılığıyla gerçekleştirildi.Bulgular: GHRL geni rs34911341 polimorfizminin genotip sıklığı, DEHB ve sağlıklı kontrol grupları arasında önemli ölçüde farklılık gösterdi(p=0,036), ancak alel sıklıkları önemli ölçüde farklılık göstermedi (p=0,207). LEP rs7799039 polimorfizmi için, iki grup arasında ne genotipne de alel frekansları farklı değildi (genotip frekansı için p=0,579; alel frekansı için p=0,558).Sonuç: Bu bulgular, GHRL rs34911341 polimorfizminin DEHB'nin gelişiminde veya sunumunda potansiyel bir rolü olduğunu göstermektedir.Bu ilişkinin altında yatan mekanizmaları açıklamak için daha fazla araştırma gerekmektedir. CR - 1. Faraone, S. V., Asherson, P., Banaschewski, T., Biederman, J., Buitelaar, J. K., Ramos-Quiroga, J. A., Rohde, L. A., Sonuga- Barke, E. J. S., Tannock, R., & Franke, B. (2015). Attention- deficit/hyperactivity disorder. 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