TY  - JOUR
T1  - The Relationship of Leptin Levels with Lipid Profile and Cardiovascular Disease Risk Factors in Obese Individuals
TT  - Obez Bireylerde Leptin Düzeylerinin Lipid Profili ve Kardiyovasküler Hastalık Risk Faktörleri ile İlişkisi
AU  - Özkan, Elife
PY  - 2025
DA  - June
Y2  - 2025
DO  - 10.54005/geneltip.1641965
JF  - Genel Tıp Dergisi
JO  - Genel Tıp Derg
PB  - Selçuk Üniversitesi
WT  - DergiPark
SN  - 2602-3741
SP  - 500
EP  - 511
VL  - 35
IS  - 3
LA  - en
AB  - Aims: This study was conducted as a systematic literature review to evaluate the effects of leptin hormone on lipid profile and cardiovascular disease (CVD) risk factors in obese individuals. Leptin is an adipokine playing a key role in energy balance and metabolic processes, and its serum levels are significantly increased in obesity. The hypothesis that increased leptin levels may negatively affect cardiovascular risk factors by contributing to dyslipidemia was investigated.Methods: PubMed, Scopus, and Web of Science databases were searched for studies published between January 2010 and October 2023. Eighteen studies meeting the inclusion criteria were analyzed. Data were collected to assess the associations between leptin levels and lipid profile parameters (total cholesterol, LDL-cholesterol, HDL-cholesterol, triglycerides) and cardiovascular risk factors, such as markers of inflammation, blood pressure (BP), and insulin resistance (IR).                                                                                                                                 Results: Positive and statistically significant associations were found between leptin levels and total cholesterol (r=0.45, p
KW  - Leptin
KW  - Obesity
KW  - Lipid Profile
KW  - Cardiovascular Disease
KW  - Dislipidemia
KW  - Insülin Resistance
KW  - inflammation
N2  - Amaç: Bu çalışma, obez bireylerde leptin hormonunun lipid profili ve kardiyovasküler hastalık risk faktörleri üzerindeki etkilerini değerlendirmek amacıyla sistematik bir literatür taraması olarak gerçekleştirilmiştir. Leptin, enerji dengesi ve metabolik süreçlerde önemli rol oynayan bir adipokindir ve obezite durumunda serum seviyeleri belirgin şekilde artar. Artan leptin düzeylerinin dislipidemiye katkıda bulunarak kardiyovasküler risk faktörlerini olumsuz etkileyebileceği hipotezi araştırılmıştır.Gereç ve Yöntemler: Ocak 2010 ile Ekim 2023 tarihleri arasında PubMed, Scopus ve Web of Science veri tabanlarında yayınlanmış çalışmalar taranmıştır. Dahil edilme kriterlerini karşılayan 18 çalışma analiz edilmiştir. Leptin düzeyleri ile lipid profili parametreleri (toplam kolesterol, LDL-kolesterol, HDL-kolesterol, trigliseritler) ve kardiyovasküler risk faktörleri (inflamasyon belirteçleri, kan basıncı, insülin direnci) arasındaki ilişkiler değerlendirilmiştir.Bulgular: Leptin düzeyleri ile toplam kolesterol (r=0.45, p
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UR  - https://doi.org/10.54005/geneltip.1641965
L1  - https://dergipark.org.tr/tr/download/article-file/4619083
ER  -