@article{article_1642420, title={INVESTIGATION OF ANTIOXIDANT AND ANTI-ALZHEIMER PROPERTIES OF NOVEL 4-AMINOANTIPYRINE-DERIVED SCHIFF BASES}, journal={İnönü Üniversitesi Sağlık Hizmetleri Meslek Yüksek Okulu Dergisi}, volume={13}, pages={707–722}, year={2025}, DOI={10.33715/inonusaglik.1642420}, author={Çınar, Ercan}, keywords={4-aminoantipirin, Alzheimer hastalığı, Antioksidanlar, Schiff bazı}, abstract={In this study, Schiff bases derived from 4-aminoantipyrine (4AAP) were synthesized and elucidated using spectroscopic methods (¹H- and ¹³C-NMR). DPPH (1,1-diphenyl-2-picrylhydrazyl) free radical scavenging test, 2,2’-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid (ABTS) radical scavenging activity, and copper ion reducing antioxidant capacity (CUPRAC) analysis were used to evaluate Schiff bases’ antioxidant potentials. Furthermore, their inhibitory potentials against cholinesterase (ChE) enzymes were investigated. The compound (4E)-4-(5-chloro-2-hydroxybenzylideneamino)-1,2-dihydro-2,3-dimethyl-1-phenylpyrazol-5-one (R3) exhibited a higher inhibition effect with an inhibitory value of 27.05 ± 0.13 µM as compared to the standard inhibitor neostigmine (33.3 ± 0.32 µM). The synthesized compounds were subjected to antioxidant tests, including DPPH, ABTS, and CUPRAC, respectively. In the DPPH experiment, the compound (4E)-4-(2-hydroxy-5-nitrobenzylideneamino)-1,2-dihydro-2,3-dimethyl-1-phenylpyrazol-5-one (R5) exhibited activity with a value of 116.79 ± 2.73 µM. However, in this test, all compounds showed lower antioxidant activity as compared to standard antioxidants such as butylated hydroxyanisole (BHA), butylated hydroxytoluene (BHT), and α-tocopherol (α-TOC). By contrast, in the ABTS assay, all compounds were active as compared to standard antioxidants, and the R3 compound showed high antioxidant activity. In the CUPRAC experiment, although the compounds showed antioxidant activity, it was not as high as that of the standard antioxidants. (4E) -4-(2-hydroxybenzylideneamino)-1,2-dihydro-2,3-dimethyl-1-phenylpyrazol-5-one (R1) compound was the most effective in the CUPRAC method.}, number={3}, publisher={İnönü Üniversitesi}