TY  - JOUR
T1  - Dolutegravir/lamivudin geçiş tedavisi izlem sonuçları
TT  - Follow-up results of dolutegravir/lamiıvudine switch therapy
AU  - Yağcı Çağlayık, Dilek
AU  - Doğanç, Fatma Burcu
PY  - 2025
DA  - August
Y2  - 2025
DO  - 10.26559/mersinsbd.1643403
JF  - Mersin Üniversitesi Sağlık Bilimleri Dergisi
JO  - Mersin Univ Saglık Bilim Derg
PB  - Mersin Üniversitesi
WT  - DergiPark
SN  - 1308-0830
SP  - 233
EP  - 243
VL  - 18
IS  - 2
LA  - tr
AB  - Amaç: Dolutegravir/lamivudin (DTG/3TC) ikili tedavisine geçiş yapılan HIV ile yaşayan bireylerdeki (HYB) ikili tedaviye geçiş sebepleri, ikili tedaviye geçişten sonra elde edilen virolojik baskılama başarısı, yan etkiler, takip sırasında böbrek fonksiyon seyrinin ortaya konulması amaçlanmıştır.  Yöntem: Tek hekimden takipli olup 2015-2021 yılları arasında ikili tedaviye geçiş yapılan  38 erişkin HYB retrospektif olarak  incelenmiştir.  Bulgular: İkili tedaviye geçişte en sık sebep, potansiyel renal toksisistelerin önlenmesi %44,7(17/38) olarak kaydedildi, median yaş 51.5, median takip süresi 54 ay olarak saptandı. Nukleozid Reverse Transkriptaz İnhibitörü (NRTI) mutasyonu (K65R, M41L, K70T/S) izlenen üç HYB de dahil olmak üzere virolojik başarısızlık hiçbir HYB’de izlenmedi. CD4+ T lenfosit sayısında anlamlı artış izlendi.  Glomerüler filtrasyon hızında (GFR) erken dönemde düzelme ve proteinüride gerileme kaydedildi. Yan etki nedeniyle kesilme oranı %5,3 (2/38) olarak izlendi. Ölüm oranı %18.4 (7/38) oranında izlendi, en sık sebebin myokard enfarktüsü (4/7) olduğu görüldü. Sonuç: Virolojik baskılama başarısı yüksek, yanetki oranı düşük bir rejim olduğu izlenen DTG/3TC , tedavi uyumu iyi olan HYB’ lerde ideal bir tedavi alternatifi olarak kabul edilebilir.
KW  - HIV
KW  - Dolutegravir
KW  - Lamivudin
N2  - Aim: Observing and revealing the switch reasons to dolutegravir/lamivudine (DTG/3TC) dual therapy, virological supression ratio,  side effects, and monitoring of renal function during follow-up after switch in people living with HIV (PLWH) were aimed. Method: Thirty-eight adult PLWH who were followed by a single physician and switched to dual therapy between 2015-2021 were retrospectively analyzed. Results: The most common reason for switching to dual therapy was the prevention of potential renal toxicities, recorded as 44.7% (17/38), the median age was 51.5 years, and the median follow-up period was 54 months. Virological failure was not observed in any PLWH, including three PLWH  that had Nucleoside Reverse Transcriptase Inhibitor (NRTI) mutation (K65R, M41L, K70T/S). There was a significant increase in CD4+ T lymphocyte number.  Glomerular filtration rate (GFR) improvement and regression of proteinuria were recorded especially in the early period. The discontinuation rate due to side effects was 5.3% (2/38). The death rate was observed to be 18.4% (7/38), and the most common cause was myocardial infarction (4/7).  Conclusion: DTG/3TC, which is observed to be a regimen with high virological suppression success and low side effect rate, can be considered as an ideal treatment alternative in PLWH.
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UR  - https://doi.org/10.26559/mersinsbd.1643403
L1  - https://dergipark.org.tr/tr/download/article-file/4625412
ER  -