@article{article_1646261, title={An Anatomy of a Fear: Clinical Outcomes of Measles-Mumps-Rubella Vaccination in Children with Egg Allergy}, journal={Phoenix Medical Journal}, volume={7}, pages={74–77}, year={2025}, DOI={10.38175/phnx.1646261}, author={Alkaya, Halil and Altaş, Uğur and Çevik, Seda and Altaş, Zeynep Meva and Özkars, Mehmet Yaşar}, keywords={Yumurta alerjisi, KKK aşısı, alerjik reaksiyon, anafilaksi, inek sütü alerjisi}, abstract={Objective: This study aimed to evaluate the frequency and clinical characteristics of allergic reactions following Measles-Mumps-Rubella (MMR) vaccination in children with egg allergy. Our aim in selecting the MMR vaccine was to better understand vaccine-related allergic reactions in children with egg allergy and to assess its reliability.
Material and Method: A retrospective analysis was conducted on 202 patients diagnosed with egg allergy who received the MMR vaccine in our clinic between 2023 and 2024. Demographic, clinical, and laboratory data were reviewed. Patients’ age, sex, concomitant allergic diseases, total IgE, specific IgE for milk, egg, and nuts, skin prick tests, and post-vaccination reactions were recorded.
Results: The median age of the patients was 12 months (range: 7-84 months), and 57.4% were male. Sensitization to cow’s milk was detected in 29.2% of the patients, while 6.9% had nut allergen sensitivity. The most common clinical conditions were urticaria (43.1%) and atopic dermatitis (36.6%). Following vaccination, only four patients (2%) developed localized rash, and none had a history of anaphylaxis.
Conclusion: No severe systemic reactions were observed following MMR vaccination in children with egg allergy. Our findings support current guidelines, suggesting that MMR vaccination can be safely administered under standard conditions in children with egg allergy. In our study, 29.2% of patients with egg allergy had cow’s milk allergy, and 6.9% had nut allergy, suggesting that food allergies are often seen together in childhood. Additionally, it is emphasized that the India-made MMR vaccines used in Turkey contain milk proteins, which may increase the risk of anaphylaxis in individuals with milk and egg allergies, highlighting the need for careful evaluation of the vaccine prospectus before vaccination in these children.}, number={2}, publisher={İbrahim İKİZCELİ}