TY  - JOUR
T1  - EVALUATION OF THE SUCCESS OF THE SYSTEMIC IMMUNE-INFLAMMATORY INDEX IN DIAGNOSING, PREDICTING COMPLICATIONS AND MORTALITY IN PATIENTS WITH PEPTIC ULCER PERFORATION PRESENTING TO THE EMERGENCY DEPARTMENT
TT  - Acil Servise Başvuran Peptik Ülser Perforasyonu Olgularının Tanısında, Komplikasyon ve Mortaliteyi Öngörmede Sistemik İmmün İnflamatuvar İndeksin Başarısının Değerlendirmesi
AU  - Kurtkulağı, Özge
AU  - Kurtkulağı, Özgür
AU  - Telafarlı, Mehmet Ali
AU  - Demirer Aydemir, Ferhan
AU  - Çelik, Ahmet Onur
AU  - Kaya, Mustafa
PY  - 2025
DA  - April
Y2  - 2025
DO  - 10.24938/kutfd.1652109
JF  - The Journal of Kırıkkale University Faculty of Medicine
JO  - Kırıkkale Uni Med J
PB  - Kırıkkale Üniversitesi
WT  - DergiPark
SN  - 2148-9645
SP  - 104
EP  - 110
VL  - 27
IS  - 1
LA  - en
AB  - Objective: Peptic ulcer perforation (PUP) is a severe complication of peptic ulcer disease, characterized by acute abdominal pain and systemic inflammation. The systemic immune-inflammatory index (SIII) has emerged as a promising biomarker for evaluating inflammation in various acute conditions, including PUP. This study investigates the diagnostic and prognostic value of SIII in PUP, focusing on its ability to predict complications and mortality. Material and Methods: This retrospective, single-center study included 150 PUP patients and 150 control patients who presented between January 2021 and December 2024. Data on the cases' demographics, vital signs, and laboratory findings were collected. Based on clinical and postoperative findings, patients were divided into complicated (CPUP) and non- complicated peptic ulcer perforation (NCPUP) groups. Statistical analyses, including ROC curve analysis, were performed to evaluate the diagnostic accuracy and prognostic value of SIII. Results: SIII levels were significantly higher in PUP patients than controls (p
KW  - Peptic ulcer perforation
KW  - systemic immune- inflammatory index
KW  - emergency department
KW  - complications
N2  - Amaç: Peptik ulkus perforasyonu (PUP), akut karın ağrısı ve sistemik inflamasyonla karakterize peptik ülser hastalığının ciddi bir komplikasyonudur. Sistemik immün-inflamatuvar indeks (SIII), PUP dahil olmak üzere çeşitli akut durumlarda inflamasyonu değerlendirmek için umut verici bir biyobelirteç olarak ortaya çıkmıştır. Bu çalışma, komplikasyonları ve mortaliteyi tahmin etme yeteneğine odaklanarak PUP'ta SIII'in tanısal ve prognostik değerliliğini araştırmaktadır. Gereç ve Yöntemler: Bu retrospektif, tek merkezli çalışmaya Ocak 2021 ile Aralık 2024 arasında başvuran 150 PUP hastası ve 150 kontrol hastası dahil edildi. Olguların demografi, vital ve laboratuvar bulgularıyla ilgili veriler toplandı. Hastalar klinik ve postoperatif bulgularına göre komplike (KPUP) ve komplike olmayan peptik ulcus perforasyonları (NKPUP) gruplarına ayrıldı. SIII'in tanısal doğruluğunu ve prognostik değerini değerlendirmek için ROC curve analiz de dahil olmak üzere istatistiksel analizler yapıldı. Bulgular: SIII düzeyleri PUP hastalarında kontrollere kıyasla önemli ölçüde daha yüksekti (p
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UR  - https://doi.org/10.24938/kutfd.1652109
L1  - https://dergipark.org.tr/tr/download/article-file/4664670
ER  -