@article{article_1652814, title={GREEN SYNTHESIS OF GOLD NANOPARTICLES USING PRUNUS CERASUS L. LEAVES EXTRACT AND STUDY OF THEIR CYTOTOXIC EFFECT ON LIVER CELL LINE}, journal={Journal of Faculty of Pharmacy of Ankara University}, volume={49}, pages={870–877}, year={2025}, DOI={10.33483/jfpau.1652814}, author={Mert Sivri, Firdevs}, keywords={Antiproliferatif aktivite, AuNP, biyosentez, Prunus cerasus L.}, abstract={Objective: Gold nanoparticles (AuNPs) possess unique chemical, physical and biological properties that make them valuable in nanotechnology applications such as drug delivery, biosensor and photothermal therapy. This study aims to synthesize AuNPs using Prunus cerasus (P. cerasus) leaves extract as a green reducing and stabilizing agent and to evaluate their structural and biological properties.
Material and Method: Green synthesis of AuNPs using P. cerasus leaves extract. The obtained AuNPs were characterized using UV-Vis spectroscopy (UV-Vis), Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), transmission electron microscopy (TEM) and zeta potential analysis to evaluate their structural, morphological and stability properties.
Result and Discussion: TEM analysis confirmed that the synthesized AuNPs were predominantly spherical and had an average size of 33±13 nm. Furthermore, the synthesized AuNPs were determined to have high stability by zeta potential analysis. Biological evaluations showed that AuNPs exhibited selective cytotoxic effects, approximately three times higher antiproliferative activity against liver cancer (HepG2) cells compared to P. cerasus leaves extract. These findings emphasize the potential of P. cerasus extract-mediated AuNPs for cancer treatment, supporting their applications in biomedical nanotechnology.}, number={3}, publisher={Ankara Üniversitesi}