@article{article_1658478, title={Diagnostic utility of pupillometry in detecting autonomic dysfunction in migraine disorders}, journal={Cukurova Medical Journal}, volume={50}, pages={299–307}, year={2025}, DOI={10.17826/cumj.1658478}, author={Türkoğlu, Ceren and İşcan, Dilek and Arslan, Elif}, keywords={Migren, otonomik disfonksiyon, pupil çapı, statik pupilometri, dinamik pupilometri}, abstract={Purpose: This study aims to comprehensively investigate autonomic nervous system dysfunction in migraine patients using automated pupillometry, a non-invasive and objective assessment method. Materials and Methods: This study was designed as a prospective, non-randomized clinical trial involving a total of 128 participants aged 18–59 years (64 migraine patients and 64 healthy controls). All participants underwent a comprehensive ophthalmological examination followed by automated pupillometry testing. Pupillometry measurements were performed under scotopic (dark), mesopic (dim light), and photopic (bright light) conditions, with subsequent recording of dynamic pupil dilation measurements. Results: The mean pupil dilation velocity in migraine patients (0.11 ± 0.45 mm/s) was found to be significantly slower compared to the healthy control group (0.13 ± 0.46 mm/s). Additionally, a significant difference was observed between the two groups in pupil diameter under mesopic conditions. Analysis of dynamic pupil dilation revealed a significant difference at the 10th second of measurement between Group I (migraine patients; 5.63 ± 0.87 mm) and Group II (healthy controls; 6.05 ± 0.95 mm). Conclusion: This study demonstrates that migraine patients exhibit slower pupil dilation velocity compared to healthy individuals, indicating autonomic nervous system dysfunction. These findings suggest that automated pupillometry may serve as a valuable, non-invasive, and objective tool for evaluating autonomic functions in migraine patients.}, number={2}, publisher={Çukurova Üniversitesi}, organization={None.}