TY  - JOUR
T1  - Kronik böbrek hastalığı olan çocuklarda mitokondriyal disfonksiyon
TT  - Mitochondrial dysfunction in children with chronic kidney disease
AU  - Girişgen, İlknur
AU  - Avcı, Esin
PY  - 2025
DA  - July
Y2  - 2025
DO  - 10.31362/patd.1658979
JF  - Pamukkale Medical Journal
JO  - Pam Tıp Derg
PB  - Pamukkale Üniversitesi
WT  - DergiPark
SN  - 1308-0865
SP  - 620
EP  - 626
VL  - 18
IS  - 3
LA  - tr
AB  - Amaç: Çocukluk çağı kronik böbrek hastalarında mitokondriyal disfonksiyonun bir göstergesi olarak serumMOTS-C düzeylerini belirlemeyi ve metabolik düzenleyici bir faktör olan bu parametrenin renal anemi,hipertansiyon, metabolik asidoz ve renal osteodistrofi ile ilişkisini araştırmayı amaçladık.Gereç ve yöntem: Çalışmaya kronik böbrek hastalığı olan 46 çocuk ve benzer yaş ve cinsiyette 46 sağlıklıçocuk dahil edildi. Hasta grubu glomerüler filtrasyon hızına göre G1-G5, etiyoloji, renal replasman tedavileri veanemi, hipertansiyon, hiperparatiroidizm ve metabolik asidoz varlığına göre alt gruplarına ayrıldı. Veriler SPSS25.0 paket programı kullanılarak analiz edildi.Bulgular: Ortalama MOTS-C düzeyi kronik böbrek hastalığı olanlarda 60,47±11,1 ng/ml iken sağlıklı çocuklarda105,2±54,7 ng/ml idi (p=0,001). MOTS-C düzeyi kronik böbrek hastalığı olan çocuklarda anlamlı derecededüşüktü. Ayrıca, böbrek nakli yapılan hastalar ile kronik diyaliz veya prediyaliz hastaları arasında anlamlı bir farkyoktu. MOTS-C düzeyleri hiperparatiroidizm ve anemisi olan hastalarda olmayanlara kıyasla anlamlı derecededüşüktü.Sonuç: Çalışmamızda, kronik böbrek hastalığı olan çocuklarda mitokondriyal hasarın erken evrelerde bilebaşladığını, renal osteodistrofi ve aneminin bu duruma katkıda bulunduğunu ve mitokondriyal inflamasyonun buhastalarda böbrek naklinden sonra bile devam ettiğini gösterdik.
KW  - Mitokondri
KW  - MOTS-C
KW  - çocuklar
KW  - kronik böbrek hastalığı
N2  - Purpose: We aimed to determine serum mitochondrial open reading frame 12S rRNA-c (MOTS-C) levels asan indicator of mitochondrial dysfunction in childhood chronic kidney disease patients and to investigate therelationship of this parameter, which is a metabolic regulatory factor, with renal anemia, hypertension metabolicacidosis and renal osteodystrophy.Materials and methods: The study included 46 children with chronic kidney disease and 46 healthy children ofsimilar age and gender. The patient group was divided into G1-G5 subgroups according to glomerular filtrationrate, etiology, renal replacement therapies and the presence of anemia, hypertension, hyperparathyroidism andmetabolic acidosis. Data were analyzed using SPSS 25.0 package program.Results: The mean MOTS-C level was 60.47±11.1 ng/ml in patients with chronic kidney disease and 105.2±54.7ng/ml in healthy children (p=0.001). The MOTS-C level was significantly lower in children with chronic kidneydisease. In addition, there was no significant difference between patients who underwent renal transplantationand patients on chronic dialysis or predialysis. MOTS-C levels were significantly lower in patients withhyperparathyroidism and anemia compared to those without.Conclusion: In our study, we demonstrated that mitochondrial damage in children with chronic kidney diseasebegins even in the early stages, renal osteodystrophy and anemia contribute to this condition, and mitochondrialinflammation persists even after kidney transplantation in these patients.
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UR  - https://doi.org/10.31362/patd.1658979
L1  - https://dergipark.org.tr/tr/download/article-file/4695466
ER  -