@article{article_1659543, title={Pleural Fluid Gas Analysis in Diagnosing and Differentiating Pulmonary Diseases}, journal={Harran Üniversitesi Tıp Fakültesi Dergisi}, volume={22}, pages={351–356}, year={2025}, DOI={10.35440/hutfd.1659543}, author={Kırhan, İdris and Çalış, Aliye Gamze and Üzer, Fatih and Karaçadır, Bedia and Turan, Hamdiye}, keywords={plevral efüzyon, pnömoni, pulmoner hastalıklar}, abstract={Background: This study aimed to evaluate pleural fluid gas parameters in patients with different underl-ying pulmonary diseases to assess their diagnostic implications.
Materials and Methods: This study conducted at Akdeniz University Pulmonology Department and Har-ran University Pulmonology Department. The retrospective study included 118 patients with pleural effusion confirmed via imaging between January 2018 and December 2024. Pleural fluid samples collec-ted by thoracentesis underwent gas analysis (pO₂, pCO₂, pH, HCO₃) and standard biochemical and cytolo-gical evaluations. Comparative analysis of gas characteristics was performed across diagnostic categories with a significance threshold of p < 0.05.
Results: In this study, 87 of 118 patients underwent arterial blood gas analysis, with a mean age of 66.4±14.2 years and 72.4% being male. Acidic, normal, and alkaline pleural fluid pH values were obser-ved in 25.3%, 26.4%, and 48.3% of patients, respectively. Most effusions were exudative (83.9%), and unilateral (81.6%), with malignancy (29.9%), pneumonia (35.6%), and heart failure (16.1%) being the leading causes. Among pneumonia cases, 45.1% had complicated effusions or empyema. Transudative effusions were associated with older age, higher pH, and lower LDH, pCO₂, and protein levels (p<0.05). Compared to other causes, pneumonia-related effusions were more likely to be exudative, occur in males, and have higher protein levels. Malignant effusions showed significantly higher HCO₃ and protein levels (p<0.05).
Conclusions: Pleural fluid gas analysis may offer valuable diagnostic insights, particularly in differentia-ting infectious from non-infectious effusions.}, number={2}, publisher={Harran Üniversitesi}, organization={Yok}