TY - JOUR T1 - Pleural Fluid Gas Analysis in Diagnosing and Differentiating Pulmonary Diseases TT - Plevral Sıvı Gaz Analizinin Pulmoner Hastalıkların Tanısında ve Ayırımında Kullanımı AU - Üzer, Fatih AU - Kırhan, İdris AU - Çalış, Aliye Gamze AU - Karaçadır, Bedia AU - Turan, Hamdiye PY - 2025 DA - June Y2 - 2025 DO - 10.35440/hutfd.1659543 JF - Harran Üniversitesi Tıp Fakültesi Dergisi PB - Harran Üniversitesi WT - DergiPark SN - 1304-9623 SP - 351 EP - 356 VL - 22 IS - 2 LA - en AB - Background: This study aimed to evaluate pleural fluid gas parameters in patients with different underl-ying pulmonary diseases to assess their diagnostic implications.Materials and Methods: This study conducted at Akdeniz University Pulmonology Department and Har-ran University Pulmonology Department. The retrospective study included 118 patients with pleural effusion confirmed via imaging between January 2018 and December 2024. Pleural fluid samples collec-ted by thoracentesis underwent gas analysis (pO₂, pCO₂, pH, HCO₃) and standard biochemical and cytolo-gical evaluations. Comparative analysis of gas characteristics was performed across diagnostic categories with a significance threshold of p < 0.05.Results: In this study, 87 of 118 patients underwent arterial blood gas analysis, with a mean age of 66.4±14.2 years and 72.4% being male. Acidic, normal, and alkaline pleural fluid pH values were obser-ved in 25.3%, 26.4%, and 48.3% of patients, respectively. Most effusions were exudative (83.9%), and unilateral (81.6%), with malignancy (29.9%), pneumonia (35.6%), and heart failure (16.1%) being the leading causes. Among pneumonia cases, 45.1% had complicated effusions or empyema. Transudative effusions were associated with older age, higher pH, and lower LDH, pCO₂, and protein levels (p<0.05). Compared to other causes, pneumonia-related effusions were more likely to be exudative, occur in males, and have higher protein levels. Malignant effusions showed significantly higher HCO₃ and protein levels (p<0.05).Conclusions: Pleural fluid gas analysis may offer valuable diagnostic insights, particularly in differentia-ting infectious from non-infectious effusions. KW - Pleural Fluid Analysis KW - Pneumonia KW - Pulmonary Diseases N2 - Amaç: Bu çalışma, farklı altta yatan pulmoner hastalıkları olan hastalarda plevral sıvı gaz parametrelerini değerlendirerek tanısal etkilerini incelemeyi amaçlamaktadır.Materyal ve Metod: Akdeniz Üniversitesi ve Harran Üniversitesi Göğüs Hastalıkları Bölümü'nde gerçek-leştirilen bu retrospektif çalışma, Ocak 2018 ile Aralık 2022 arasında görüntüleme ile doğrulanmış plev-ral efüzyonu olan 118 hastayı içermektedir. Torasentez ile toplanan plevral sıvı örneklerine gaz analizi (pO₂, pCO₂, pH, HCO₃) ve standart biyokimyasal ve sitolojik değerlendirmeler yapıldı. Gaz özellikleri, tanı kategorileri arasında karşılaştırmalı olarak analiz edildi ve anlamlılık eşiği p < 0,05 olarak belirlendi.Bulgular: Bu çalışmada, 118 hastanın 87’sine arteriyel kan gazı analizi uygulandı; hastaların ortalama yaşı 66,4±14,2 yıl olup, %72,4’ü erkekti. Plevral sıvı pH değeri hastaların %25,3’ünde asidik, %26,4’ünde normal ve %48,3’ünde alkalen olarak saptandı. Plevral sıvıların büyük çoğunluğu (%83,9) eksüdatif ve %81,6’sı unilateraldı. En sık nedenler malignite (%29,9), pnömoni (%35,6) ve kalp yetmezliği (%16,1) olarak belirlendi. Pnömoni tanısı alan olguların %45,1’inde komplike efüzyon veya ampiyem vardı. Tran-südatif efüzyonlar daha ileri yaş, daha yüksek pH ve daha düşük LDH, pCO₂ ve protein düzeyleri ile ilişki-liydi (p<0,05). 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