@article{article_1667940, title={Platelet Indices in Distinguishing Thrombotic vs Embolic Ischemic Stroke}, journal={Celal Bayar Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi}, volume={12}, pages={296–304}, year={2025}, DOI={10.34087/cbusbed.1667940}, author={Alpar, Suleyman and Özden, Muhammed Furkan and Tatliparmak, Ali Cankut and Aydoğdu Umaç, Gülbin and Yılmaz, Sarper}, keywords={İskemik inme, trombotik inme, embolik inme, trombosit indeksleri, inme sınıflandırması, ortalama trombosit hacmi, trombosit dağılım genişliği, inme patofizyolojisi}, abstract={Aim; Ischemic stroke, a critical condition, can be categorized into thrombotic and embolic subtypes. Understanding the differences in platelet indices between these subtypes can provide valuable insights. Method; This cross-sectional study included patients diagnosed with acute ischemic stroke in the emergency department. Thrombotic and embolic subtypes were compared in terms of demographics, comorbidities, blood results and platelet indices. The primary outcome of the study was comparison of platelet indices between thrombotic and embolic ischemic stroke patients. Results; The study included a total of 233 patients, with 130 (55.8%) diagnosed with thrombotic ischemic stroke and 103 (44.2%) with embolic ischemic stroke. Thrombotic stroke patients were older in age (p=0.01), had higher rates of coronary artery disease (p=0.019). But the embolic stroke patients and higher rate of atrial fibrillation (p <0.001). Thrombotic stroke cases demonstrated significantly higher platelet distribution width (PDW) values (17 [16.3 – 17.8] vs. 13.7 [11.8 – 16], p < 0.001) and mean platelet volume (MPV) values (10.8 ± 1.4 vs. 9.71 ± 1.24, p < 0.001) compared to embolic stroke cases. The platelet count (p=0.352) and plateletcrit (p=0.106) did not differ significantly among groups. Conclusion; This study reveals distinctive platelet index patterns between thrombotic and embolic ischemic stroke subtypes. While PDW and MPV were higher in thrombotic patients, platelet count and plateletcrit were not significantly different between groups. The findings suggest a potential association between elevated PDW and MPV values and heightened platelet activation in thrombotic strokes.}, number={2}, publisher={Manisa Celal Bayar Üniversitesi}